Elafin
| peptidase inhibitor 3 | |||||||
|---|---|---|---|---|---|---|---|
| معرفات | |||||||
| أسماء بديلة | protease inhibitor 3, skin-derived (SKALP), protease inhibitor WAP3, PI3, skin-derived antileukoproteinase, SKALP, elafin, trappin-2, WAP four-disulfide core domain 14, PI-3, elastase-specific inhibitor, WAP four-disulfide core domain protein 14, ESI, pre-elafin, peptidase inhibitor 3, skin-derived | ||||||
| معرفات خارجية | |||||||
| نمط التعبير عن الحمض النووي الريبوزي | |||||||
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| المزيد من بيانات التعبير المرجعية | |||||||
| تماثلات متسلسلة | |||||||
| أنواع | الإنسان | الفأر | |||||
| أنتريه | n/a | ||||||
| Ensembl | n/a | n/a | |||||
| يونيبروت |
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| RefSeq (رنا مرسال.) |
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| RefSeq (بروتين) |
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| الموقع (UCSC | n/a | ||||||
| بحث ببمد | n/a | ||||||
| ويكي بيانات | |||||||
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Elafin (None) هوَ بروتين يُشَفر بواسطة جين Elafin في الإنسان.[1][2][3]
الوظيفة
الأهمية السريرية
المراجع
- ^ "Entrez Gene: PI3 peptidase inhibitor 3, skin-derived (SKALP)". مؤرشف من الأصل في 2010-12-05.
- ^ Molhuizen HO، Zeeuwen PL، Olde Weghuis D، Geurts van Kessel A، Schalkwijk J (فبراير 1994). "Assignment of the human gene encoding the epidermal serine proteinase inhibitor SKALP (PI3) to chromosome region 20q12→q13". Cytogenet Cell Genet. ج. 66 ع. 2: 129–31. DOI:10.1159/000133683. PMID:8287685.
- ^ Clauss A، Lilja H، Lundwall A (نوفمبر 2002). "A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein". Biochem J. ج. 368 ع. Pt 1: 233–42. DOI:10.1042/BJ20020869. PMC:1222987. PMID:12206714.
قراءة متعمقة
- Sallenave JM (2003). "The role of secretory leukocyte proteinase inhibitor and elafin (elastase-specific inhibitor/skin-derived antileukoprotease) as alarm antiproteinases in inflammatory lung disease". Respir. Res. ج. 1 ع. 2: 87–92. DOI:10.1186/rr18. PMC:59548. PMID:11667971.
{استشهاد بدورية محكمة}: صيانة الاستشهاد: دوي مجاني غير معلم (link) - Saheki T، Ito F، Hagiwara H، وآخرون (1992). "Primary structure of the human elafin precursor preproelafin deduced from the nucleotide sequence of its gene and the presence of unique repetitive sequences in the prosegment". Biochem. Biophys. Res. Commun. ج. 185 ع. 1: 240–5. DOI:10.1016/S0006-291X(05)80981-7. PMID:1339270.
- Sallenave JM، Marsden MD، Ryle AP (1992). "Isolation of elafin and elastase-specific inhibitor (ESI) from bronchial secretions. Evidence of sequence homology and immunological cross-reactivity". Biol. Chem. Hoppe-Seyler. ج. 373 ع. 1: 27–33. DOI:10.1515/bchm3.1992.373.1.27. PMID:1536690.
- Chang A، Schalkwijk J، Happle R، van de Kerkhof PC (1990). "Elastase-inhibiting activity in scaling skin disorders". Acta Derm. Venereol. ج. 70 ع. 2: 147–51. PMID:1969201.
- Schalkwijk J، de Roo C، de Jongh GJ (1991). "Skin-derived antileukoproteinase (SKALP), an elastase inhibitor from human keratinocytes. Purification and biochemical properties". Biochim. Biophys. Acta. ج. 1096 ع. 2: 148–54. DOI:10.1016/0925-4439(91)90053-c. PMID:2001428.
- Sallenave JM، Ryle AP (1991). "Purification and characterization of elastase-specific inhibitor. Sequence homology with mucus proteinase inhibitor". Biol. Chem. Hoppe-Seyler. ج. 372 ع. 1: 13–21. DOI:10.1515/bchm3.1991.372.1.13. PMID:2039600.
- Wiedow O، Schröder JM، Gregory H، وآخرون (1990). "Elafin: an elastase-specific inhibitor of human skin. Purification, characterization, and complete amino acid sequence". J. Biol. Chem. ج. 265 ع. 25: 14791–5. PMID:2394696.
- Molhuizen HO، Alkemade HA، Zeeuwen PL، وآخرون (1993). "SKALP/elafin: an elastase inhibitor from cultured human keratinocytes. Purification, cDNA sequence, and evidence for transglutaminase cross-linking". J. Biol. Chem. ج. 268 ع. 16: 12028–32. PMID:7685029.
- Zhang M، Zou Z، Maass N، Sager R (1995). "Differential expression of elafin in human normal mammary epithelial cells and carcinomas is regulated at the transcriptional level". Cancer Res. ج. 55 ع. 12: 2537–41. PMID:7780965.
- Sallenave JM، Silva A (1993). "Characterization and gene sequence of the precursor of elafin, an elastase-specific inhibitor in bronchial secretions". Am. J. Respir. Cell Mol. Biol. ج. 8 ع. 4: 439–45. DOI:10.1165/ajrcmb/8.4.439. PMID:8476637.
- Tsunemi M، Matsuura Y، Sakakibara S، Katsube Y (1996). "Crystal structure of an elastase-specific inhibitor elafin complexed with porcine pancreatic elastase determined at 1.9 A resolution". Biochemistry. ج. 35 ع. 36: 11570–6. DOI:10.1021/bi960900l. PMID:8794736.
- Pfundt R، van Ruissen F، van Vlijmen-Willems IM، وآخرون (1996). "Constitutive and inducible expression of SKALP/elafin provides anti-elastase defense in human epithelia". J. Clin. Invest. ج. 98 ع. 6: 1389–99. DOI:10.1172/JCI118926. PMC:507565. PMID:8823304.
- Steinert PM، Marekov LN (1997). "Direct evidence that involucrin is a major early isopeptide cross-linked component of the keratinocyte cornified cell envelope". J. Biol. Chem. ج. 272 ع. 3: 2021–30. DOI:10.1074/jbc.272.3.2021. PMID:8999895.
{استشهاد بدورية محكمة}: صيانة الاستشهاد: دوي مجاني غير معلم (link) - Francart C، Dauchez M، Alix AJ، Lippens G (1997). "Solution structure of R-elafin, a specific inhibitor of elastase". J. Mol. Biol. ج. 268 ع. 3: 666–77. DOI:10.1006/jmbi.1997.0983. PMID:9171290.
- Kuijpers AL، Pfundt R، Zeeuwen PL، وآخرون (1998). "SKALP/elafin gene polymorphisms are not associated with pustular forms of psoriasis". Clin. Genet. ج. 54 ع. 1: 96–101. DOI:10.1111/j.1399-0004.1998.tb03703.x. PMID:9727750.
- Mihaila A، Tremblay GM (2001). "Human alveolar macrophages express elafin and secretory leukocyte protease inhibitor". Z. Naturforsch. C. ج. 56 ع. 3–4: 291–7. PMID:11371023.
- Simpson AJ، Wallace WA، Marsden ME، وآخرون (2001). "Adenoviral augmentation of elafin protects the lung against acute injury mediated by activated neutrophils and bacterial infection". J. Immunol. ج. 167 ع. 3: 1778–86. DOI:10.4049/jimmunol.167.3.1778. PMID:11466403.
- Sumi Y، Inoue N، Azumi H، وآخرون (2002). "Expression of tissue transglutaminase and elafin in human coronary artery: implication for plaque instability". Atherosclerosis. ج. 160 ع. 1: 31–9. DOI:10.1016/S0021-9150(01)00542-1. PMID:11755920.
