APBB3

APBB3
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	2DYQ, 2YSC
Identifikatori
Aliasi	APBB3
Vanjski ID-jevi	OMIM: 602711 MGI: 108404 HomoloGene: 21221 GeneCards: APBB3
Lokacija gena (čovjek)
Hrom.	Hromosom 5 (čovjek)
Kraj	140,564,781 bp
Lokacija gena (miš)
Hrom.	Hromosom 18 (miš)
Kraj	36,812,419 bp
Ontologija gena
Molekularna funkcija	• transcription factor binding; • amyloid-beta binding; • GO:0001948, GO:0016582 vezivanje za proteine;
Ćelijska komponenta	• jedro; • actin cytoskeleton; • citosol; • citoplazma;
Biološki proces	• GO:0009373 regulation of transcription, DNA-templated;
	Izvori:Amigo / QuickGO
Ortolozi
	10307
	225372
	ENSG00000113108
	ENSMUSG00000117679
	O95704; Q96DX9
	Q8R1C9
NM_133176; NM_006051; NM_133172; NM_133173; NM_133174;
	NM_133175
	NM_146085; NM_001357512
NP_006042; NP_573418; NP_573419; NP_573420; NP_006042.3;
	NP_573418.2; NP_573419.2; NP_573420.2
	NP_666197; NP_001344441
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Član 3 porodice A4 vezanja B-amiloidnih beta prekursorskih proteina jest protein koji je kod ljudi kodiran genom APBB3.^[5]^[6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 486 aminokiselina, а molekulska težina 52.585 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MLGKDYMLAI	ILVNCDDDLW	GDHSLEVEAG	LPPGWRKIHD	AAGTYYWHVP
SGSTQWQRPT	WELGDAEDPG	TGTEGIWGLR	PPKGRSFSSL	ESSLDRSNSL
SWYGGESYIQ	SMEPGAKCFA	VRSLGWVEVP	EEDLAPGKSS	IAVNNCIQQL
AQTRSRSQPP	DGAWGEGQNM	LMILKKDAMS	LVNPLDHSLI	HCQPLVHIRV
WGVGSSKGRD	RDFAFVASDK	DSCMLKCHVF	CCDVPAKAIA	SALHGLCAQI
LSERVEVSGD	ASCCSPDPIS	PEDLPRQVEL	LDAVSQAAQK	YEALYMGTLP
VTKAMGMDVL	NEAIGTLTAR	GDRNAWVPTM	LSVSDSLMTA	HPIQAEASTE
EEPLWQCPVR	LVTFIGVGRD	PHTFGLIADL	GRQSFQCAAF	WCQPHAGGLS
EAVQAACMVQ	YQKCLVASAA	RGKAWGAQAR	ARLRLKRTSS	MDSPGGPLPL
PLLKGGVGGA	GATPRKRGVF	SFLDAFRLKP	SLLHMP

Funkcija

Protein kodiran ovim genom član je porodice proteina APBB. Nalazi se u citoplazmi i veže se na unutarćelijski domen Alzheimerove bolesti prekursora beta-amiloidnog protein (APP), kao i za druge APP-u slične proteine. Smatra se da protein kodiran ovim genom može modulirati internalizaciju APP-a. Za ovaj gen je pronađeno više varijanti transkripta koje kodiraju nekoliko različitih izoformi.^[6]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000113108 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000117679 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ermekova KS, Zambrano N, Linn H, Minopoli G, Gertler F, Russo T, Sudol M (Jan 1998). "The WW domain of neural protein FE65 interacts with proline-rich motifs in Mena, the mammalian homolog of Drosophila enabled". J Biol Chem. 272 (52): 32869–77. doi:10.1074/jbc.272.52.32869. PMID 9407065.
^ ^a ^b "Entrez Gene: APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3".
^ "UniProt, O95704" (jezik: engleski). Pristupljeno 12. 10. 2021.

Dopunska literatura

Tanahashi H, Tabira T (1999). "Molecular cloning of human Fe65L2 and its interaction with the Alzheimer's beta-amyloid precursor protein". Neurosci. Lett. 261 (3): 143–6. doi:10.1016/S0304-3940(98)00995-1. PMID 10081969. S2CID 54307954.
Tanahashi H, Tabira T (1999). "Genome structure and chromosomal mapping of the gene for Fe65L2 interacting with Alzheimer's beta-amyloid precursor protein". Biochem. Biophys. Res. Commun. 258 (2): 385–9. doi:10.1006/bbrc.1999.0639. PMID 10329396.
Tanahashi H, Tabira T (2002). "Characterization of an amyloid precursor protein-binding protein Fe65L2 and its novel isoforms lacking phosphotyrosine-interaction domains". Biochem. J. 367 (Pt 3): 687–95. doi:10.1042/BJ20020562. PMC 1222940. PMID 12153398.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Chang Y, Tesco G, Jeong WJ, et al. (2004). "Generation of the beta-amyloid peptide and the amyloid precursor protein C-terminal fragment gamma are potentiated by FE65L1". J. Biol. Chem. 278 (51): 51100–7. doi:10.1074/jbc.M309561200. PMID 14527950.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

Vanjski linkovi

APBB3 lokacija ljudskog genoma UCSC Genome Browser.

APBB3 detalji ljudskog genoma u UCSC Genome Browser.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000113108 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000117679 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9407065-5] Ermekova KS, Zambrano N, Linn H, Minopoli G, Gertler F, Russo T, Sudol M (Jan 1998). "The WW domain of neural protein FE65 interacts with proline-rich motifs in Mena, the mammalian homolog of Drosophila enabled". J Biol Chem. 272 (52): 32869–77. doi:10.1074/jbc.272.52.32869. PMID 9407065.

[entrez-6] "Entrez Gene: APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3".

[UniProt-7] "UniProt, O95704" (jezik: engleski). Pristupljeno 12. 10. 2021.

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