FAM114A2

FAM114A2
Identifikatori
Aliasi	FAM114A2
Vanjski ID-jevi	MGI: 1917629 HomoloGene: 10270 GeneCards: FAM114A2
Lokacija gena (čovjek)
Hrom.	Hromosom 5 (čovjek)
Kraj	154,038,936 bp
Lokacija gena (miš)
Hrom.	Hromosom 11 (miš)
Kraj	57,409,443 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• purine nucleotide binding;
Ćelijska komponenta	• ćelijska komponenta;
Biološki proces	• GO:0022610 biološki proces;
	Izvori:Amigo / QuickGO
Ortolozi
	10827
	67726
	ENSG00000055147
	ENSMUSG00000020523
	Q9NRY5
	Q8VE88
	NM_018691; NM_001317993; NM_001317994; NM_001317995
	NM_001168667; NM_001168668; NM_026342
	NP_001304922; NP_001304923; NP_001304924; NP_061161
	NP_001162138; NP_001162139; NP_080618
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

FAM114A2 otvoreni okvir čitanja 3 hromosoma 5 jest gen na koji kod ljudi kodira protein FAM114A2. Funkcija proteina nije dobro poznata. FAM114A2 je, međutim, visoko konzerviran kod sisara s homolozima i u gljiva i u biljaka.

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 505 aminokiselina, а molekulska težina 55.468 Da.^[5]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MSDKDDIETP	LLTEAAPILE	DGNCEPAKNS	ESVDQGAKPE	SKSEPVVSTR
KRPETKPSSD	LETSKVLPIQ	DNVSKDVPQT	RWGYWGSWGK	SILSSASATV
ATVGQGISNV	IEKAETSLGI	PGPSEISTEV	KYVAGETNAK	ENENSSPVAG
AFGVFSTIST	AVQSTGKSVI	SGGLDALEFI	GKKTMDVIAE	GDPGFKRTKG
LMNRNATLSQ	VLREAKEKEE	IRTSNEVTVE	TDKKTHYGLL	FDEFQGLSHL
EALEMLSQES	EIKVKSILNS	LSGEELETLK	VELEQLKETF	SLAEFCEEEE
EEKKGDEDFT	KDITELFSQL	HVSSKPEKLA	RARNTAHEWI	RKSLTKPLAE
NEEGEKQSEA	ENTEQVNKNS	IEDIHAFAIR	SLAELTACSI	ELFHKTAALV
LHGRKQEVTA	IERSQTLSQM	TIVLCKELSS	LSKEFTTCLT	TAGVKEMADV
LNPLITAVFL	EASNSASYIQ	DAFQLLLPVL	EISLIENKIE	SHRHELQGQK
PLLEH

Gen

Gen FAM114A2 nalazi se na hromosomu 5, sekvenca 5q31–33).^[6] Ovaj gen ima 14 egzona koji se protežu kroz njegovu sekvencu. Kodirajuća sekvenca duga je 2.886 baznih parova sa 5 'UTR od 94 bazna para i 3' UTR od 1.273 parova baza.^[7] Elsprimira se na visokim nivoima u većini ljudskih tkiva.^[6] Također je izrazito eksprimira i u tkivima ljudskog mozga.^[8]

Protein

Protein FAM114A2 dug je 505 aminokiselina^[7] sa molekulskom težinom od 55,5 kdal i izoelektričnom tačkom od 4,66.^[9] It is predicted to stay in the nucleus after translation ^[10] Postoje dokazi da c5orf3 stupa u interakciju s drugim proteinom nepoznate funkcije iz hromosoma 5, c5orf4.^[11] Smatra se da ovaj protein uključuje P-petlju ^[12] što ukazuje na ulogu u vezanju ATP i/ili GTP.^[13]

Vrsta	Pristupni broj	Identitet
Macaca mulatta	XM_001102467	78,1%
Pan troglodytes	XM_518045	89,7%
Bos taurus	NP_001033166	85,6%
Pongo abelii	XM_002816109	87,8%
Mus musculus	NM_026342.3	79%
Callithrix jacchus	XP_002744467	94,7%

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000055147 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020523 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "UniProt, Q9NRY5" (jezik: engleski). Pristupljeno 13. 10. 2021.
^ ^a ^b FAM114A2 Gene - GeneCards | F1142 Protein | F1142 Antibody
^ ^a ^b Homo sapiens family with sequence similarity 114, member A2 (FAM114A2) - Nucleotide - NCBI
^ Allen Brain Atlas: http://human.brain-map.org/search?type=mi Arhivirano 18. 8. 2011. na Wayback Machine
^ Biology workbench: http://seqtool.sdsc.edu/CGI/BW.cgi# Arhivirano 11. 8. 2003. na Wayback Machine!
^ PSORT WWW Server
^ STRING: http://string-db.org/newstring_cgi/show_network_section.pl Arhivirano 15. 5. 2013. na Wayback Machine.
^ "STRING: Functional protein association networks".
^ Saraste M, Sibbald PR, Wittinghofer A (novembar 1990). "The P-loop--a common motif in ATP- and GTP-binding proteins". Trends Biochem. Sci. 15 (11): 430–4. doi:10.1016/0968-0004(90)90281-f. PMID 2126155.

Dopunska literatura

Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

Vanjski linkovi

Lokacija ljudskog genoma FAM114A2 i stranica sa detaljima o genu FAM114A2 u UCSC Genome Browseru.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000055147 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020523 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[UniProt-5] "UniProt, Q9NRY5" (jezik: engleski). Pristupljeno 13. 10. 2021.

[www.genecards.org-6] FAM114A2 Gene - GeneCards | F1142 Protein | F1142 Antibody

[ncbi-7] Homo sapiens family with sequence similarity 114, member A2 (FAM114A2) - Nucleotide - NCBI

[8] Allen Brain Atlas: http://human.brain-map.org/search?type=mi Arhivirano 18. 8. 2011. na Wayback Machine

[9] Biology workbench: http://seqtool.sdsc.edu/CGI/BW.cgi# Arhivirano 11. 8. 2003. na Wayback Machine!

[10] PSORT WWW Server

[11] STRING: http://string-db.org/newstring_cgi/show_network_section.pl Arhivirano 15. 5. 2013. na Wayback Machine.

[12] "STRING: Functional protein association networks".

[13] Saraste M, Sibbald PR, Wittinghofer A (novembar 1990). "The P-loop--a common motif in ATP- and GTP-binding proteins". Trends Biochem. Sci. 15 (11): 430–4. doi:10.1016/0968-0004(90)90281-f. PMID 2126155.

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