BACH1

BACH1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2IHC
Dynodwyr
Cyfenwau	BACH1, BACH-1, BTBD24, BTB domain and CNC homolog 1
Dynodwyr allanol	OMIM: 602751 HomoloGene: 916 GeneCards: BACH1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • DNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0050372 ubiquitin-protein transferase activity • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0001948, GO:0016582 protein binding • heme binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cydrannau o'r gell • cytoplasm • cytosol • Cul3-RING ubiquitin ligase complex • cnewyllyn cell Prosesau biolegol • GO:0009373 regulation of transcription, DNA-templated • GO:1901227 negative regulation of transcription by RNA polymerase II • regulation of transcription involved in G1/S transition of mitotic cell cycle • transcription, DNA-templated • regulation of transcription from RNA polymerase II promoter in response to hypoxia • GO:0100026 DNA repair • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • regulation of transcription involved in G2/M transition of mitotic cell cycle • protein ubiquitination • transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	571	n/a
Ensembl	ENSG00000156273	n/a
UniProt	O14867	n/a
RefSeq (mRNA)	NM_001011545 NM_001186 NM_206866	n/a
RefSeq (protein)	NP_001177 NP_996749	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn BACH1 yw BACH1 a elwir hefyd yn BTB domain and CNC homolog 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 21, band 21q21.3.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn BACH1.

• BACH-1
• BTBD24

• "The electrophilic character of quinones is essential for the suppression of Bach1. ". Toxicology. 2017. PMID 28645578.
• "BACH1 silencing by siRNA inhibits migration of HT-29 colon cancer cells through reduction of metastasis-related genes. ". Biomed Pharmacother. 2016. PMID 27657827.
• "BACH1, the master regulator gene: A novel candidate target for cancer therapy. ". Gene. 2016. PMID 27108804.
• "Bach1 Induces Endothelial Cell Apoptosis and Cell-Cycle Arrest through ROS Generation. ". Oxid Med Cell Longev. 2016. PMID 27057283.
• "Correlation of BACH1 and Hemoglobin E/Beta-Thalassemia Globin Expression.". Turk J Haematol. 2016. PMID 26377036.