FOXC1

FOXC1
Dynodwyr
Cyfenwau	FOXC1, ARA, FKHL7, FREAC-3, FREAC3, IGDA, IHG1, IRID1, RIEG3, forkhead box C1, ASGD3
Dynodwyr allanol	OMIM: 601090 HomoloGene: 20373 GeneCards: FOXC1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • sequence-specific DNA binding • RNA polymerase II transcription regulatory region sequence-specific DNA binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0001948, GO:0016582 protein binding • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding • DNA binding, bending • transcription coactivator binding • GO:0001105 transcription coactivator activity • transcription factor binding • promoter-specific chromatin binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cydrannau o'r gell • nucleoplasm • cnewyllyn cell • cytosol Prosesau biolegol • eye development • somitogenesis • Notch signaling pathway • skeletal system development • glycosaminoglycan metabolic process • positive regulation of hematopoietic progenitor cell differentiation • GO:0009373 regulation of transcription, DNA-templated • neural crest cell development • paraxial mesoderm formation • ossification • vascular endothelial growth factor signaling pathway • collagen fibril organization • maintenance of lens transparency • heart morphogenesis • in utero embryonic development • cardiac muscle cell proliferation • lymph vessel development • transcription, DNA-templated • embryonic heart tube development • positive regulation of hematopoietic stem cell differentiation • odontogenesis of dentin-containing tooth • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • ventricular cardiac muscle tissue morphogenesis • heart development • blood vessel remodeling • brain development • vascular endothelial growth factor receptor signaling pathway • negative regulation of lymphangiogenesis • blood vessel development • GO:1901313 positive regulation of gene expression • mesenchymal cell differentiation • mesenchymal cell development • artery morphogenesis • ovarian follicle development • negative regulation of angiogenesis • camera-type eye development • regulation of organ growth • germ cell migration • lacrimal gland development • negative regulation of mitotic cell cycle • negative regulation of apoptotic process involved in outflow tract morphogenesis • transcription by RNA polymerase II • endochondral ossification • cell population proliferation • positive regulation of epithelial to mesenchymal transition • cell migration • positive regulation of DNA binding • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • cellular response to epidermal growth factor stimulus • positive regulation of core promoter binding • GO:1901227 negative regulation of transcription by RNA polymerase II • cerebellum development • positive regulation of keratinocyte differentiation • glomerular epithelium development • ureteric bud development • kidney development • chemokine-mediated signaling pathway • cellular response to chemokine • angiogenesis • multicellular organism development • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • anatomical structure morphogenesis • cell differentiation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2296	n/a
Ensembl	ENSG00000054598	n/a
UniProt	Q12948	n/a
RefSeq (mRNA)	NM_001453	n/a
RefSeq (protein)	NP_001444	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn FOXC1 yw FOXC1 a elwir hefyd yn Forkhead box C1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 6, band 6p25.3.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn FOXC1.

• "FOXC1 overexpression is a marker of poor response to anthracycline-based adjuvant chemotherapy in sporadic triple-negative breast cancer. ". Cancer Chemother Pharmacol. 2017. PMID 28493031.
• "FOXC1: an emerging marker and therapeutic target for cancer. ". Oncogene. 2017. PMID 28288141.
• "Brachydactyly type E in an Italian family with 6p25 trisomy. ". Eur J Med Genet. 2017. PMID 28111183.
• "The role and the potential regulatory pathways of high expression of forkhead box C1 in promoting tumor growth and metastasis of basal-like breast cancer. ". J BUON. 2016. PMID 27685901.
• "A Novel Homozygous Mutation in FOXC1 Causes Axenfeld Rieger Syndrome with Congenital Glaucoma.". PLoS One. 2016. PMID 27463523.