HPGD

HPGD
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2GDZ
Dynodwyr
Cyfenwau	HPGD, 15-PGDH, PGDH, PGDH1, PHOAR1, SDR36C1, hydroxyprostaglandin dehydrogenase 15-(NAD), 15-hydroxyprostaglandin dehydrogenase
Dynodwyr allanol	OMIM: 601688 HomoloGene: 68095 GeneCards: HPGD
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • NAD binding • 15-hydroxyprostaglandin dehydrogenase (NAD+) activity • catalytic activity • prostaglandin E receptor activity • NAD+ binding • oxidoreductase activity • protein homodimerization activity Cydrannau o'r gell • nucleoplasm • basolateral plasma membrane • extracellular exosome • cytoplasm • cytosol • extracellular space Prosesau biolegol • prostaglandin metabolic process • thrombin-activated receptor signaling pathway • lipid metabolism • negative regulation of cell cycle • fatty acid metabolic process • lipoxygenase pathway • genedigaeth • lipoxin metabolic process • transforming growth factor beta receptor signaling pathway • ovulation • ductus arteriosus closure • response to lipopolysaccharide • kidney development • female pregnancy • response to estradiol • positive regulation of apoptotic process • response to ethanol • positive regulation of vascular associated smooth muscle cell proliferation • long-chain fatty acid biosynthetic process • lipoxin biosynthetic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3248	n/a
Ensembl	ENSG00000164120	n/a
UniProt	P15428	n/a
RefSeq (mRNA)	NM_000860 NM_001145816 NM_001256301 NM_001256305 NM_001256306 NM_001256307 NM_001363574	n/a
RefSeq (protein)	NP_000851 NP_001139288 NP_001243230 NP_001243234 NP_001243235 NP_001243236 NP_001350503	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn HPGD yw HPGD a elwir hefyd yn 15-hydroxyprostaglandin dehydrogenase [NAD(+)] (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 4, band 4q34.1.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn HPGD.

• "Expression and Cellular Localization of 15-Hydroxy-Prostaglandin-Dehydrogenase in Abdominal Aortic Aneurysm. ". PLoS One. 2015. PMID 26287481.
• "15-PGDH expression as a predictive factor response to neoadjuvant chemotherapy in advanced gastric cancer. ". Int J Clin Exp Pathol. 2015. PMID 26261578.
• "A Common Mutation and a Novel Mutation in the HPGD Gene in Nine Patients with Primary Hypertrophic Osteoarthropathy. ". Calcif Tissue Int. 2015. PMID 26135126.
• "[Genetic diagnosis for a Chinese Han family with primary hypertrophic osteoarthropathy]. ". Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2015. PMID 25863089.
• "15-Deoxy-Δ12,14-prostaglandin J2 induces expression of 15-hydroxyprostaglandin dehydrogenase through Elk-1 activation in human breast cancer MDA-MB-231 cells.". Mutat Res. 2014. PMID 25773924.