MAP3K5

MAP3K5
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2CLQ, 3VW6, 4BF2, 4BHN, 4BIB, 4BIC, 4BID, 4BIE
Dynodwyr
Cyfenwau	MAP3K5, ASK1, MAPKKK5, MEKK5, mitogen-activated protein kinase kinase kinase 5
Dynodwyr allanol	OMIM: 602448 HomoloGene: 38114 GeneCards: MAP3K5
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• transferase activity; • protein kinase activity; • nucleotide binding; • protein homodimerization activity; • metal ion binding; • kinase activity; • GO:0001948, GO:0016582 protein binding; • protein phosphatase binding; • MAP kinase kinase kinase activity; • ATP binding; • protein kinase binding; • magnesium ion binding; • protein serine/threonine kinase activity; • protein domain specific binding; • identical protein binding;
Cydrannau o'r gell	• cytoplasm; • protein kinase complex; • Reticwlwm endoplasmig; • IRE1-TRAF2-ASK1 complex; • cytosol; • external side of plasma membrane; • GO:0009327 protein-containing complex;
Prosesau biolegol	• intrinsic apoptotic signaling pathway in response to oxidative stress; • positive regulation of protein phosphorylation; • phosphorylation; • immune system process; • regulation of cell death; • positive regulation of neuron death; • positive regulation of JNK cascade; • response to endoplasmic reticulum stress; • cellular response to reactive nitrogen species; • MAPK cascade; • protein phosphorylation; • JNK cascade; • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; • intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; • response to ischemia; • positive regulation of myoblast differentiation; • positive regulation of apoptotic process; • apoptotic signaling pathway; • p38MAPK cascade; • programmed necrotic cell death; • innate immune response; • GO:0022415 viral process; • cellular response to hydrogen peroxide; • GO:0097285 apoptotic process; • cellular response to tumor necrosis factor; • positive regulation of cardiac muscle cell apoptotic process; • positive regulation of p38MAPK cascade; • wound healing; • positive regulation of JUN kinase activity; • positive regulation of vascular associated smooth muscle cell proliferation; • endothelial cell apoptotic process; • cellular response to amino acid starvation; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • stress-activated MAPK cascade;
	Sources:Amigo / QuickGO
Orthologau
	4217
	n/a
	ENSG00000197442
	n/a
	Q99683
	n/a
	NM_005923
	n/a
	NP_005914
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn MAP3K5 yw MAP3K5 a elwir hefyd yn Mitogen-activated protein kinase kinase kinase 5 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 6, band 6q23.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn MAP3K5.

ASK1
MEKK5
MAPKKK5

Llyfryddiaeth

"Dynamic Phosphorylation of Apoptosis Signal Regulating Kinase 1 (ASK1) in Response to Oxidative and Electrophilic Stress. ". Chem Res Toxicol. 2016. PMID 27989136.
"MicroRNA-Mediated Down-Regulation of Apoptosis Signal-Regulating Kinase 1 (ASK1) Attenuates the Apoptosis of Human Mesenchymal Stem Cells (MSCs) Transplanted into Infarcted Heart. ". Int J Mol Sci. 2016. PMID 27775615.
"4SC-202 activates ASK1-dependent mitochondrial apoptosis pathway to inhibit hepatocellular carcinoma cells. ". Biochem Biophys Res Commun. 2016. PMID 26773495.
"Genetic variation in the TNF/TRAF2/ASK1/p38 kinase signaling pathway as markers for postoperative pulmonary complications in lung cancer patients. ". Sci Rep. 2015. PMID 26165383.
"[ASK1-MAP kinase signaling pathway as a therapeutic target for human diseases].". Nihon Rinsho. 2014. PMID 24912301.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] MAP3K5 - Cronfa NCBI

[1]

[2]