POU2F1

POU2F1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1CQT, 1E3O, 1GT0, 1HF0, 1O4X, 1OCT, 1POG
Dynodwyr
Cyfenwau	POU2F1, OCT1, OTF1, oct-1B, POU class 2 homeobox 1, Oct1Z
Dynodwyr allanol	OMIM: 164175 HomoloGene: 37658 GeneCards: POU2F1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • sequence-specific DNA binding • GO:0001948, GO:0016582 protein binding • RNA polymerase II core promoter sequence-specific DNA binding • GO:0000983 RNA polymerase II general transcription initiation factor activity • DNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding Cydrannau o'r gell • Reticwlwm endoplasmig • cnewyllyn cell • intracellular membrane-bounded organelle • nucleoplasm • RNA polymerase II transcription regulator complex Prosesau biolegol • GO:0045996 negative regulation of transcription, DNA-templated • GO:0009373 regulation of transcription, DNA-templated • transcription, DNA-templated • snRNA transcription by RNA polymerase II • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • cytokine-mediated signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5451	n/a
Ensembl	ENSG00000143190	n/a
UniProt	P14859	n/a
RefSeq (mRNA)	NM_001198783 NM_001198786 NM_002697 NM_001365848 NM_001365849	n/a
RefSeq (protein)	NP_001185712 NP_001185715 NP_002688 NP_001352777 NP_001352778	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn POU2F1 yw POU2F1 a elwir hefyd yn POU class 2 homeobox 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 1, band 1q24.2.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn POU2F1.

• 37165
• OTF1
• oct-1B

• "Loss-of-function polymorphisms in the organic cation transporter OCT1 are associated with reduced postoperative tramadol consumption. ". Pain. 2016. PMID 27541716.
• "Involvement of transcription factor Oct-1 in the regulation of JAK-STAT signaling pathway in cells of Burkitt lymphoma. ". Dokl Biochem Biophys. 2016. PMID 27417729.
• "Genetic Polymorphisms in Organic Cation Transporter 1 Attenuates Hepatic Metformin Exposure in Humans. ". Clin Pharmacol Ther. 2017. PMID 28380657.
• "hOCT1 gene expression predict for optimal response to Imatinib in Tunisian patients with chronic myeloid leukemia. ". Cancer Chemother Pharmacol. 2017. PMID 28286932.
• "Increased level of Oct-1 protein in tumor cells modulates cellular response to anticancer drugs.". Dokl Biochem Biophys. 2016. PMID 27599509.