TRAF4

TRAF4
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2EOD, 2YUC, 3ZJB, 4K8U, 4M4E
Dynodwyr
Cyfenwau	TRAF4, CART1, MLN62, RNF83, TNF receptor associated factor 4
Dynodwyr allanol	OMIM: 602464 HomoloGene: 3173 GeneCards: TRAF4
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • zinc ion binding • metal ion binding • GO:0001948, GO:0016582 protein binding • WW domain binding • thioesterase binding • tumor necrosis factor receptor binding • protein kinase binding • ubiquitin protein ligase binding • identical protein binding Cydrannau o'r gell • cytoplasm • bilen • bicellular tight junction • Cellbilen • cell junction • perinuclear region of cytoplasm • Cytosgerbwd • cnewyllyn cell • GO:0009327 protein-containing complex • intracellular anatomical structure Prosesau biolegol • regulation of apoptotic process • activation of NF-kappaB-inducing kinase activity • positive regulation of JNK cascade • positive regulation of protein homodimerization activity • respiratory gaseous exchange by respiratory system • multicellular organism development • respiratory tube development • GO:0072468 signal transduction • positive regulation of protein kinase activity • GO:0097285 apoptotic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	9618	n/a
Ensembl	ENSG00000076604	n/a
UniProt	Q9BUZ4	n/a
RefSeq (mRNA)	NM_004295 NM_145751	n/a
RefSeq (protein)	NP_004286	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TRAF4 yw TRAF4 a elwir hefyd yn TNF receptor-associated factor 4 a TNF receptor associated factor 4 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 17, band 17q11.2.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TRAF4.

• CART1
• MLN62
• RNF83

• "Knockdown of TRAF4 expression suppresses osteosarcoma cell growth in vitro and in vivo. ". Int J Mol Med. 2014. PMID 25270078.
• "Structure of the TRAF4 TRAF domain with a coiled-coil domain and its implications for the TRAF4 signalling pathway. ". Acta Crystallogr D Biol Crystallogr. 2014. PMID 24419373.
• "TRAF4 promotes the growth and invasion of colon cancer through the Wnt/β-catenin pathway. ". Int J Clin Exp Pathol. 2015. PMID 25973026.
• "[TRAF4, a multifaceted protein involved in carcinoma progression]. ". Biol Aujourdhui. 2014. PMID 25840457.
• "TRAF4 enhances osteosarcoma cell proliferation and invasion by Akt signaling pathway.". Oncol Res. 2014. PMID 25700355.