Befloxatone
Befloxatone
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Names
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Preferred IUPAC name
(5R)-5-(Methoxymethyl)-3-{4-[(3R)-4,4,4-trifluoro-3-hydroxybutoxy]phenyl}-1,3-oxazolidin-2-one
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Identifiers
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ChEMBL
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ChemSpider
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KEGG
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UNII
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InChI=1S/C15H18F3NO5/c1-22-9-12-8-19(14(21)24-12)10-2-4-11(5-3-10)23-7-6-13(20)15(16,17)18/h2-5,12-13,20H,6-9H2,1H3/t12-,13-/m1/s1 YKey: IALVDLPLCLFBCF-CHWSQXEVSA-N YInChI=1/C15H18F3NO5/c1-22-9-12-8-19(14(21)24-12)10-2-4-11(5-3-10)23-7-6-13(20)15(16,17)18/h2-5,12-13,20H,6-9H2,1H3/t12-,13-/m1/s1 Key: IALVDLPLCLFBCF-CHWSQXEVBB
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O=C2O[C@H](CN2c1ccc(OCC[C@@H](O)C(F)(F)F)cc1)COC
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Properties
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C15H18F3NO5
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Molar mass
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349.30233
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Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Chemical compound
Befloxatone (MD-370,503) is a reversible inhibitor of monoamine oxidase A.[1][2]
References
- ^ Emilien, G (March 1999). "Befloxatone (Synthelabo)". IDrugs. 2 (3): 247–253. PMID 16160936.
- ^ Warot, Dominique; Berlin, Ivan; Patat, Alain; Durrieu, Geneviève; Zieleniuk, Isabelle; Puech, Alain J (October 1996). "Effects of Befloxatone, a Reversible Selective Monoamine Oxidase-A Inhibitor, on Psychomotor Function and Memory in Healthy Subjects". The Journal of Clinical Pharmacology. 1552-4604. 36 (10): 942–950. doi:10.1002/j.1552-4604.1996.tb04762.x. PMID 8930782. S2CID 36177710.
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Non-specific | AAADTooltip Aromatic L-amino acid decarboxylase | |
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MAOTooltip Monoamine oxidase | |
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Phenethylamines (dopamine, epinephrine, norepinephrine) | PAHTooltip Phenylalanine hydroxylase | |
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THTooltip Tyrosine hydroxylase | |
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DBHTooltip Dopamine beta-hydroxylase | |
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PNMTTooltip Phenylethanolamine N-methyltransferase |
- Inhibitors: CGS-19281A
- SKF-64139
- SKF-7698
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COMTTooltip Catechol-O-methyl transferase | |
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Tryptamines (serotonin, melatonin) | TPHTooltip Tryptophan hydroxylase | |
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AANATTooltip Serotonin N-acetyl transferase | |
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ASMTTooltip Acetylserotonin O-methyltransferase | |
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Histamine | HDCTooltip Histidine decarboxylase | |
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HNMTTooltip Histamine N-methyltransferase |
- Substrates→Products: Histamine→N-Methylhistamine
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DAOTooltip Diamine oxidase |
- Substrates→Products: Histamine→Imidazole acetic acid
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