Carbohydrate (chondroitin 4) sulfotransferase 13
Carbohydrate (chondroitin 4) sulfotransferase 13 is a protein that is encoded in humans by the CHST13 gene .[5]
Function
The protein encoded by this gene belongs to the sulfotransferase 2 family. It is localized to the golgi membrane , and catalyzes the transfer of sulfate to the C4 hydroxyl of beta-1,4-linked N-acetylgalactosamine (GalNAc) flanked by glucuronic acid residue in chondroitin . Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices .
References
Further reading
Kang HG, Evers MR, Xia G, Baenziger JU, Schachner M (September 2002). "Molecular cloning and characterization of chondroitin-4-O-sulfotransferase-3. A novel member of the HNK-1 family of sulfotransferases" . The Journal of Biological Chemistry . 277 (38): 34766–72. doi :10.1074/jbc.M204907200 . PMID 12080076 .
Valente B, Campos PA, do Rosário VE, Silveira H (October 2010). "Natural frequency of polymorphisms linked to the chondroitin 4-sulfotransferase genes and its association with placental malaria". Transactions of the Royal Society of Tropical Medicine and Hygiene . 104 (10): 687–9. doi :10.1016/j.trstmh.2010.05.005 . PMID 20580388 .
Hiraoka N, Nakagawa H, Ong E, Akama TO, Fukuda MN, Fukuda M (June 2000). "Molecular cloning and expression of two distinct human chondroitin 4-O-sulfotransferases that belong to the HNK-1 sulfotransferase gene family" . The Journal of Biological Chemistry . 275 (26): 20188–96. doi :10.1074/jbc.M002443200 . PMID 10781601 .
This article incorporates text from the United States National Library of Medicine , which is in the public domain .
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