D-galactose 1-dehydrogenase

d-galactose 1-dehydrogenase
Identifiers
EC no.1.1.1.48
CAS no.9028-54-0
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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In enzymology, a d-galactose 1-dehydrogenase (EC 1.1.1.48) is an enzyme that catalyzes the chemical reaction

d-galactose + NAD+ d-galactono-1,4-lactone + NADH + H+

Thus, the two substrates of this enzyme are d-galactose and NAD+, whereas its 3 products are d-galactono-1,4-lactone, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is d-galactose:NAD+ 1-oxidoreductase. Other names in common use include d-galactose dehydrogenase, beta-galactose dehydrogenase, and NAD+-dependent d-galactose dehydrogenase. This enzyme participates in galactose metabolism.

References

  • De Ley J, Doudoroff M (1957). "The metabolism of D-galactose in Pseudomonas saccharophila". J. Biol. Chem. 227 (2): 745–57. PMID 13462997.
  • Hu, ASL; Cline AL (1964). "The regulation of some sugar dehydrogenases in a pseudomonad". Biochim. Biophys. Acta. 93: 237–245. doi:10.1016/0304-4165(64)90371-x. PMID 14251301.