DUSP13

DUSP13
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2GWO, 2PQ5
Identifiers
Aliases	DUSP13, BEDP, DUSP13A, DUSP13B, MDSP, SKRP4, TMDP, dual specificity phosphatase 13
External IDs	OMIM: 613191 MGI: 1351599 HomoloGene: 121602 GeneCards: DUSP13
Gene location (Human)
Chr.	Chromosome 10 (human)
End	75,109,221 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	21,801,249 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; triceps brachii muscle; ; biceps brachii; ; vastus lateralis muscle; ; thoracic diaphragm; ; deltoid muscle; ; body of tongue; ; tibialis anterior muscle; ; left ventricle; ; pancreatic ductal cell;
	Top expressed in
	spermatid; ; triceps brachii muscle; ; seminiferous tubule; ; temporal muscle; ; skeletal muscle tissue; ; extraocular muscle; ; sternocleidomastoid muscle; ; digastric muscle; ; quadriceps femoris muscle; ; vastus lateralis muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein tyrosine phosphatase activity; phosphoprotein phosphatase activity; hydrolase activity; protein tyrosine/serine/threonine phosphatase activity; phosphatase activity; protein binding;
Cellular component	cytoplasm;
Biological process	protein dephosphorylation; peptidyl-tyrosine dephosphorylation; dephosphorylation; spermatogenesis; meiosis;
	Sources:Amigo / QuickGO
Orthologs
	51207
	27389
	ENSG00000079393
	ENSMUSG00000021768
	Q6B8I1; Q9UII6
	Q6B8I0; Q9QYJ7
NM_001007271; NM_001007272; NM_001007273; NM_001007274; NM_001007275;
	NM_016364; NM_001320842; NM_001320843; NM_001363514
NM_001007268; NM_013849; NM_001374075; NM_001374077; NM_001374078;
	NM_001374079
NP_001007272; NP_001007273; NP_001007274; NP_001307771; NP_001307772;
	NP_057448; NP_001350443; NP_057448.3; NP_001307772.1
NP_001007269; NP_038877; NP_001361004; NP_001361006; NP_001361007;
	NP_001361008; NP_038877.2
	Wikidata
View/Edit Human	View/Edit Mouse

Dual specificity phosphatase 13 is an enzyme that in humans is encoded by the DUSP13 gene.^[5]

Function

Members of the protein tyrosine phosphatase superfamily cooperate with protein kinases to regulate cell proliferation and differentiation. This superfamily is separated into two families based on the substrate that is dephosphorylated. One family, the dual specificity phosphatases (DSPs) acts on both phosphotyrosine and phosphoserine/threonine residues. This gene encodes different but related DSP proteins through the use of non-overlapping open reading frames, alternate splicing, and presumed different transcription promoters. Expression of the distinct proteins from this gene has been found to be tissue specific and the proteins may be involved in postnatal development of specific tissues. A protein encoded by the upstream ORF was found in skeletal muscle, whereas the encoded protein from the downstream ORF was found only in testis. In mouse, a similar pattern of expression was found. Multiple alternatively spliced transcript variants were described, but the full-length sequence of only some were determined.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000079393 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021768 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: DUSP13 dual specificity phosphatase 13".

Nakamura K, Shima H, Watanabe M, et al. (2000). "Molecular cloning and characterization of a novel dual-specificity protein phosphatase possibly involved in spermatogenesis". Biochem. J. 344 Pt 3 (Pt 3): 819–25. doi:10.1042/0264-6021:3440819. PMC 1220704. PMID 10585869.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462. PMID 15164054.
Chen HH, Luche R, Wei B, Tonks NK (2004). "Characterization of two distinct dual specificity phosphatases encoded in alternative open reading frames of a single gene located on human chromosome 10q22.2". J. Biol. Chem. 279 (40): 41404–13. doi:10.1074/jbc.M405286200. PMID 15252030.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Kim SJ, Jeong DG, Yoon TS, et al. (2007). "Crystal structure of human TMDP, a testis-specific dual specificity protein phosphatase: implications for substrate specificity". Proteins. 66 (1): 239–45. doi:10.1002/prot.21197. PMID 17044055. S2CID 30555597.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000079393 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021768 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: DUSP13 dual specificity phosphatase 13".

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DUSP13

Function

References

Further reading