Impentamine
Impentamine
Names
IUPAC name
5-(1H -imidazol-5-yl)pentan-1-amine
Identifiers
ChEMBL
ChemSpider
MeSH
Impentamine
UNII
InChI=1S/C8H15N3/c9-5-3-1-2-4-8-6-10-7-11-8/h6-7H,1-5,9H2,(H,10,11)
N Key: MZCJWLAXZRFUPI-UHFFFAOYSA-N
N InChI=1/C8H15N3/c9-5-3-1-2-4-8-6-10-7-11-8/h6-7H,1-5,9H2,(H,10,11)
Key: MZCJWLAXZRFUPI-UHFFFAOYAF
Properties
C8 H15 N3
Molar mass
153.2248 g/mol
Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
Chemical compound
Impentamine is a histamine antagonist selective for the H3 subtype .[ 1] [ 2]
References
^ Vollinga, RC; Menge, WM; Leurs, R; Timmerman, H (1995). "Homologs of histamine as histamine H3 receptor antagonists: a new potent and selective H3 antagonist, 4(5)-(5-aminopentyl)-1H-imidazole". Journal of Medicinal Chemistry . 38 (2): 266– 71. doi :10.1021/jm00002a008 . PMID 7830269 .
^ Van Der Goot, H; Timmerman, H (2000). "Selective ligands as tools to study histamine receptors". European Journal of Medicinal Chemistry . 35 (1): 5– 20. doi :10.1016/S0223-5234(00)00101-X . PMID 10733599 .
H1
Agonists Antagonists
Others: Atypical antipsychotics (e.g., aripiprazole , asenapine , brexpiprazole , brilaroxazine , clozapine , iloperidone , olanzapine , paliperidone , quetiapine , risperidone , ziprasidone , zotepine )
Phenylpiperazine antidepressants (e.g., hydroxynefazodone , nefazodone , trazodone , triazoledione )
Tetracyclic antidepressants (e.g., amoxapine , loxapine , maprotiline , mianserin , mirtazapine , oxaprotiline )
Tricyclic antidepressants (e.g., amitriptyline , butriptyline , clomipramine , desipramine , dosulepin (dothiepin) , doxepin , imipramine , iprindole , lofepramine , nortriptyline , protriptyline , trimipramine )
Typical antipsychotics (e.g., chlorpromazine , flupenthixol , fluphenazine , loxapine , perphenazine , prochlorperazine , thioridazine , thiothixene )
Unknown/unsorted: Azanator
Belarizine
Elbanizine
Flotrenizine
GSK1004723
Napactadine
Tagorizine
Trelnarizine
Trenizine
H2
H3
H4
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