MXD3

MXD3
Identifiers
Aliases	MXD3, BHLHC13, MAD3, MYX, MAX dimerization protein 3
External IDs	OMIM: 609450; MGI: 104987; HomoloGene: 32333; GeneCards: MXD3; OMA:MXD3 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	177,312,757 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	55,477,636 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; granulocyte; ; monocyte; ; blood; ; ganglionic eminence; ; spleen; ; bone marrow; ; mucosa of transverse colon; ; trabecular bone; ; gastric mucosa;
	Top expressed in
	lumbar spinal ganglion; ; fossa; ; ascending aorta; ; internal carotid artery; ; aortic valve; ; thymus; ; crypt of lieberkuhn of small intestine; ; external carotid artery; ; condyle; ; ventricular zone;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; protein binding; protein dimerization activity; RNA polymerase II transcription regulatory region sequence-specific DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus; RNA polymerase II transcription regulator complex;
Biological process	negative regulation of transcription, DNA-templated; regulation of transcription, DNA-templated; transcription, DNA-templated; negative regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	83463
	17121
	ENSG00000213347
	ENSMUSG00000021485
	Q9BW11
	Q80US8
	NM_031300; NM_001142935; NM_001394986; NM_001394987
	NM_016662
	NP_001136407; NP_112590; NP_112590.1
	NP_057871
	Wikidata
View/Edit Human	View/Edit Mouse

MAX dimerization protein 3 is a protein that in humans is encoded by the MXD3 gene located on Chromosome 5.^[5]^[6]

MXD3 is a basic helix-loop-helix protein belonging to a subfamily of MAX-interacting proteins. This protein competes with MYC for binding to MAX to form a sequence-specific DNA-binding complex.^[6] MXD3 is a transcriptional repressor that is specifically expressed during S phase of the cell cycle.^[7] The protein is implicated in both normal neural development and in the development of brain cancer. In medulloblastoma cells, MXD3 binds E-box sequences, leading to increased cell proliferation at moderate MXD3 levels but increased cell death and apoptosis at higher expression levels.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000213347 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021485 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hurlin PJ, Quéva C, Koskinen PJ, Steingrímsson E, Ayer DE, Copeland NG, Jenkins NA, Eisenman RN (November 1995). "Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation". EMBO J. 14 (22): 5646–59. doi:10.1002/j.1460-2075.1995.tb00252.x. PMC 394680. PMID 8521822.
^ ^a ^b "Entrez Gene: MXD3 MAX dimerization protein 3".
^ Fox EJ, Wright SC (February 2003). "The transcriptional repressor gene Mad3 is a novel target for regulation by E2F1". Biochem J. 370 (1): 307–13. doi:10.1042/bj20021583. PMC 1223166. PMID 12444919.
^ Barisone GA, Ngo T, Tran M, Cortes D, Shahi MH, Nguyen TV, Perez-Lanza D, Matayasuwan W, Díaz E (July 2012). "Role of MXD3 in proliferation of DAOY human medulloblastoma cells". PLOS ONE. 7 (7): e38508. Bibcode:2012PLoSO...738508B. doi:10.1371/journal.pone.0038508. PMC 3393725. PMID 22808009.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000213347 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021485 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8521822-5] Hurlin PJ, Quéva C, Koskinen PJ, Steingrímsson E, Ayer DE, Copeland NG, Jenkins NA, Eisenman RN (November 1995). "Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation". EMBO J. 14 (22): 5646–59. doi:10.1002/j.1460-2075.1995.tb00252.x. PMC 394680. PMID 8521822.

[entrez-6] "Entrez Gene: MXD3 MAX dimerization protein 3".

[pmid12444919-7] Fox EJ, Wright SC (February 2003). "The transcriptional repressor gene Mad3 is a novel target for regulation by E2F1". Biochem J. 370 (1): 307–13. doi:10.1042/bj20021583. PMC 1223166. PMID 12444919.

[pmid22808009-8] Barisone GA, Ngo T, Tran M, Cortes D, Shahi MH, Nguyen TV, Perez-Lanza D, Matayasuwan W, Díaz E (July 2012). "Role of MXD3 in proliferation of DAOY human medulloblastoma cells". PLOS ONE. 7 (7): e38508. Bibcode:2012PLoSO...738508B. doi:10.1371/journal.pone.0038508. PMC 3393725. PMID 22808009.

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