NARS (gene)

NARS1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4ZYA
Identifiers
Aliases	NARS1, NARS, NEDMILG, NEDMILEG, ASNRS, asparaginyl-tRNA synthetase 1, asparaginyl-tRNA synthetase
External IDs	OMIM: 108410 MGI: 1917473 HomoloGene: 68404 GeneCards: NARS1
Gene location (Human)
Chr.	Chromosome 18 (human)
End	57,622,213 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	64,649,723 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; pancreatic ductal cell; ; Brodmann area 23; ; middle temporal gyrus; ; kidney tubule; ; parotid gland; ; Region I of hippocampus proper; ; renal medulla; ; germinal epithelium; ; bronchial epithelial cell;
	Top expressed in
	facial motor nucleus; ; Paneth cell; ; motor neuron; ; lacrimal gland; ; calvaria; ; seminal vesicula; ; anterior horn of spinal cord; ; parotid gland; ; medial vestibular nucleus; ; crypt of lieberkuhn of small intestine;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	aminoacyl-tRNA ligase activity; nucleotide binding; ligase activity; asparagine-tRNA ligase activity; ATP binding; nucleic acid binding;
Cellular component	extracellular exosome; mitochondrion; cytoplasm; cytosol;
Biological process	protein biosynthesis; asparaginyl-tRNA aminoacylation; tRNA aminoacylation for protein translation;
	Sources:Amigo / QuickGO
Orthologs
	4677
	70223
	ENSG00000134440
	ENSMUSG00000024587
	O43776
	Q8BP47
	NM_004539
	NM_001142950; NM_027350; NM_001377021; NM_001377022; NM_001377023
	NP_004530
	NP_001136422; NP_081626
	Wikidata
View/Edit Human	View/Edit Mouse

Asparaginyl-tRNA synthetase, cytoplasmic is an enzyme that in humans is encoded by the NARS gene.^[5]^[6]^[7]

Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Asparaginyl-tRNA synthetase is localized to the cytoplasm and belongs to the class II family of tRNA synthetases. The N-terminal domain represents the signature sequence for the eukaryotic asparaginyl-tRNA synthetases.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000134440 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024587 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Cirullo RE, Arredondo-Vega FX, Smith M, Wasmuth JJ (May 1983). "Isolation and characterization of interspecific heat-resistant hybrids between a temperature-sensitive chinese hamster cell asparaginyl-tRNA synthetase mutant and normal human leukocytes: assignment of human asnS gene to chromosome 18". Somatic Cell Genet. 9 (2): 215–33. doi:10.1007/BF01543178. PMID 6836455. S2CID 42353500.
^ Beaulande M, Tarbouriech N, Hartlein M (Feb 1998). "Human cytosolic asparaginyl-tRNA synthetase: cDNA sequence, functional expression in Escherichia coli and characterization as human autoantigen". Nucleic Acids Res. 26 (2): 521–4. doi:10.1093/nar/26.2.521. PMC 147268. PMID 9421509.
^ ^a ^b "Entrez Gene: NARS asparaginyl-tRNA synthetase".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Shiba K, Motegi H, Yoshida M, Noda T (1999). "Human asparaginyl-tRNA synthetase: molecular cloning and the inference of the evolutionary history of Asx-tRNA synthetase family". Nucleic Acids Res. 26 (22): 5045–51. doi:10.1093/nar/26.22.5045. PMC 147956. PMID 9801298.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000134440 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024587 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid6836455-5] Cirullo RE, Arredondo-Vega FX, Smith M, Wasmuth JJ (May 1983). "Isolation and characterization of interspecific heat-resistant hybrids between a temperature-sensitive chinese hamster cell asparaginyl-tRNA synthetase mutant and normal human leukocytes: assignment of human asnS gene to chromosome 18". Somatic Cell Genet. 9 (2): 215–33. doi:10.1007/BF01543178. PMID 6836455. S2CID 42353500.

[pmid9421509-6] Beaulande M, Tarbouriech N, Hartlein M (Feb 1998). "Human cytosolic asparaginyl-tRNA synthetase: cDNA sequence, functional expression in Escherichia coli and characterization as human autoantigen". Nucleic Acids Res. 26 (2): 521–4. doi:10.1093/nar/26.2.521. PMC 147268. PMID 9421509.

[entrez-7] "Entrez Gene: NARS asparaginyl-tRNA synthetase".

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[5]

[6]

[7]

NARS (gene)

References

Further reading