PPP3CB

PPP3CB
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4OR9, 4ORA, 4ORC
Identifiers
Aliases	PPP3CB, CALNA2, CALNB, CNA2, PP2Bbeta, protein phosphatase 3 catalytic subunit beta
External IDs	OMIM: 114106 MGI: 107163 HomoloGene: 56429 GeneCards: PPP3CB
Gene location (Human)
Chr.	Chromosome 10 (human)
End	73,496,024 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	20,596,641 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; biceps brachii; ; middle temporal gyrus; ; vastus lateralis muscle; ; superior frontal gyrus; ; orbitofrontal cortex; ; Brodmann area 23; ; parietal lobe; ; postcentral gyrus; ; deltoid muscle;
	Top expressed in
	subiculum; ; triceps brachii muscle; ; olfactory tubercle; ; medial dorsal nucleus; ; temporal muscle; ; nucleus accumbens; ; sternocleidomastoid muscle; ; medial geniculate nucleus; ; digastric muscle; ; prefrontal cortex;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; phosphoprotein phosphatase activity; protein dimerization activity; protein serine/threonine phosphatase activity; metal ion binding; calmodulin binding; protein binding; enzyme binding; protein phosphatase 2B binding; hydrolase activity; calmodulin-dependent protein phosphatase activity;
Cellular component	cytosol; T-tubule; plasma membrane; calcineurin complex; nucleoplasm; Z disc; cytoplasm; glutamatergic synapse;
Biological process	response to cytokine; lymphangiogenesis; regulation of insulin secretion; calcineurin-NFAT signaling cascade; memory; learning; regulation of synaptic plasticity; T cell homeostasis; positive regulation of transcription, DNA-templated; negative regulation of T cell mediated cytotoxicity; T cell proliferation; Fc-epsilon receptor signaling pathway; protein phosphorylation; heart development; T cell differentiation; axon extension; regulation of gene expression; social behavior; positive regulation of insulin secretion involved in cellular response to glucose stimulus; locomotion involved in locomotory behavior; T cell activation; positive regulation of transcription by RNA polymerase II; calcium-ion regulated exocytosis; signal transduction; dephosphorylation; Wnt signaling pathway, calcium modulating pathway; protein dephosphorylation; regulation of synaptic vesicle endocytosis; calcineurin-mediated signaling;
	Sources:Amigo / QuickGO
Orthologs
	5532
	19056
	ENSG00000107758
	ENSMUSG00000021816
	P16298
	P48453
	NM_001142353; NM_001142354; NM_001289968; NM_001289969; NM_021132
	NM_008914; NM_001310426; NM_001310427
	NP_001135825; NP_001135826; NP_001276897; NP_001276898; NP_066955
	NP_001297355; NP_001297356; NP_032940
	Wikidata
View/Edit Human	View/Edit Mouse

Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform (PP2BB) is an enzyme that in humans is encoded by the PPP3CB gene.^[5]^[6]^[7]^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000107758 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021816 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Universal protein resource accession number P16298 for "Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform" at UniProt.
^ Giri PR, Higuchi S, Kincaid RL (Jan 1992). "Chromosomal mapping of the human genes for the calmodulin-dependent protein phosphatase (calcineurin) catalytic subunit". Biochem Biophys Res Commun. 181 (1): 252–8. doi:10.1016/S0006-291X(05)81410-X. PMID 1659808.
^ Guerini D, Krinks MH, Sikela JM, Hahn WE, Klee CB (Mar 1990). "Isolation and sequence of a cDNA clone for human calcineurin B, the Ca2+-binding subunit of the Ca2+/calmodulin-stimulated protein phosphatase". DNA. 8 (9): 675–82. doi:10.1089/dna.1.1989.8.675. PMID 2558868.
^ "Entrez Gene: PPP3CB protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform".

Chen MX, Chen YH, Cohen PT (1992). "Polymerase chain reactions using Saccharomyces, Drosophila and human DNA predict a large family of protein serine/threonine phosphatases". FEBS Lett. 306 (1): 54–8. doi:10.1016/0014-5793(92)80836-6. PMID 1321058. S2CID 31397906.
McPartlin AE, Barker HM, Cohen PT (1991). "Identification of a third alternatively spliced cDNA encoding the catalytic subunit of protein phosphatase 2B beta". Biochim. Biophys. Acta. 1088 (2): 308–10. doi:10.1016/0167-4781(91)90069-x. PMID 1848109.
Guerini D, Klee CB (1990). "Cloning of human calcineurin A: evidence for two isozymes and identification of a polyproline structural domain". Proc. Natl. Acad. Sci. U.S.A. 86 (23): 9183–7. doi:10.1073/pnas.86.23.9183. PMC 298458. PMID 2556704.
Shibasaki F, McKeon F (1995). "Calcineurin functions in Ca(2+)-activated cell death in mammalian cells". J. Cell Biol. 131 (3): 735–43. doi:10.1083/jcb.131.3.735. PMC 2120616. PMID 7593193.
Muramatsu T, Kincaid RL (1993). "Molecular cloning of a full-length cDNA encoding the catalytic subunit of human calmodulin-dependent protein phosphatase (calcineurin A alpha)". Biochim. Biophys. Acta. 1178 (1): 117–20. doi:10.1016/0167-4889(93)90117-8. PMID 8392375.
Kissinger CR, Parge HE, Knighton DR, et al. (1996). "Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex". Nature. 378 (6557): 641–4. Bibcode:1995Natur.378..641K. doi:10.1038/378641a0. PMID 8524402. S2CID 4337105.
Wang MG, Yi H, Guerini D, et al. (1997). "Calcineurin A alpha (PPP3CA), calcineurin A beta (PPP3CB) and calcineurin B (PPP3R1) are located on human chromosomes 4, 10q21→q22 and 2p16→p15 respectively". Cytogenet. Cell Genet. 72 (2–3): 236–41. doi:10.1159/000134198. PMID 8978785.
Sun L, Youn HD, Loh C, et al. (1998). "Cabin 1, a negative regulator for calcineurin signaling in T lymphocytes". Immunity. 8 (6): 703–11. doi:10.1016/S1074-7613(00)80575-0. PMID 9655484.
Aramburu J, Garcia-Cózar F, Raghavan A, et al. (1998). "Selective inhibition of NFAT activation by a peptide spanning the calcineurin targeting site of NFAT". Mol. Cell. 1 (5): 627–37. doi:10.1016/S1097-2765(00)80063-5. PMID 9660947.
Okamura H, Aramburu J, García-Rodríguez C, et al. (2000). "Concerted dephosphorylation of the transcription factor NFAT1 induces a conformational switch that regulates transcriptional activity". Mol. Cell. 6 (3): 539–50. doi:10.1016/S1097-2765(00)00053-8. PMID 11030334.
Frey N, Richardson JA, Olson EN (2001). "Calsarcins, a novel family of sarcomeric calcineurin-binding proteins". Proc. Natl. Acad. Sci. U.S.A. 97 (26): 14632–7. Bibcode:2000PNAS...9714632F. doi:10.1073/pnas.260501097. PMC 18970. PMID 11114196.
Esau C, Boes M, Youn HD, et al. (2001). "Deletion of calcineurin and myocyte enhancer factor 2 (MEF2) binding domain of Cabin1 results in enhanced cytokine gene expression in T cells". J. Exp. Med. 194 (10): 1449–59. doi:10.1084/jem.194.10.1449. PMC 2193671. PMID 11714752.
Frey N, Olson EN (2002). "Calsarcin-3, a novel skeletal muscle-specific member of the calsarcin family, interacts with multiple Z-disc proteins". J. Biol. Chem. 277 (16): 13998–4004. doi:10.1074/jbc.M200712200. PMID 11842093.
Banerjee A, Banks AS, Nawijn MC, et al. (2002). "Cutting edge: Suppressor of cytokine signaling 3 inhibits activation of NFATp". J. Immunol. 168 (9): 4277–81. doi:10.4049/jimmunol.168.9.4277. PMID 11970967.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Bennasser Y, Badou A, Tkaczuk J, Bahraoui E (2003). "Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha". Virology. 303 (1): 174–80. doi:10.1006/viro.2002.1676. PMID 12482669.
Genescà L, Aubareda A, Fuentes JJ, et al. (2003). "Phosphorylation of calcipressin 1 increases its ability to inhibit calcineurin and decreases calcipressin half-life". Biochem. J. 374 (Pt 2): 567–75. doi:10.1042/BJ20030267. PMC 1223619. PMID 12809556.
Bell O, Gaberman E, Kilav R, et al. (2005). "The protein phosphatase calcineurin determines basal parathyroid hormone gene expression". Mol. Endocrinol. 19 (2): 516–26. doi:10.1210/me.2004-0108. PMID 15514034. S2CID 27672093.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000107758 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021816 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Universal protein resource accession number P16298 for "Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform" at UniProt.

[pmid1659808-6] Giri PR, Higuchi S, Kincaid RL (Jan 1992). "Chromosomal mapping of the human genes for the calmodulin-dependent protein phosphatase (calcineurin) catalytic subunit". Biochem Biophys Res Commun. 181 (1): 252–8. doi:10.1016/S0006-291X(05)81410-X. PMID 1659808.

[pmid2558868-7] Guerini D, Krinks MH, Sikela JM, Hahn WE, Klee CB (Mar 1990). "Isolation and sequence of a cDNA clone for human calcineurin B, the Ca2+-binding subunit of the Ca2+/calmodulin-stimulated protein phosphatase". DNA. 8 (9): 675–82. doi:10.1089/dna.1.1989.8.675. PMID 2558868.

[entrez-8] "Entrez Gene: PPP3CB protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform".

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PPP3CB

References

Further reading