PERP
Protein-coding gene in the species Homo sapiens
p53 apoptosis effector related to PMP-22 is a plasma membrane protein that, in humans, is encoded by the PERP gene .[5] [6]
PERP is a direct transcriptional target of p53 , but its transcription can also be regulated by other transcription factors.[7]
PERP is important for skin development, and loss of PERP is associated with the development and progression of several types of human cancers .[7]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000112378 - Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000019851 - Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Hildebrandt T, Preiherr J, Tarbe N, Klostermann S, Van Muijen GN, Weidle UH (Dec 2000). "Identification of THW, a putative new tumor suppressor gene". Anticancer Res . 20 (5A): 2801–2809. PMID 11062687 . ^ "Entrez Gene: PERP PERP, TP53 apoptosis effector" .^ a b Roberts O, Paraoan L (Dec 2020). "PERP-ing into diverse mechanisms of cancer pathogenesis: Regulation and role of the p53/p63 effector PERP". Biochim Biophys Acta Rev Cancer . 1874 (1): 188393. doi :10.1016/j.bbcan.2020.188393 . PMID 32679166 . S2CID 220631324 .
Further reading
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene . 138 (1–2): 171–174. doi :10.1016/0378-1119(94)90802-8 . PMID 8125298 . Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene . 200 (1–2): 149–156. doi :10.1016/S0378-1119(97)00411-3 . PMID 9373149 . Attardi LD, Reczek EE, Cosmas C, et al. (2000). "PERP, an apoptosis-associated target of p53, is a novel member of the PMP-22/gas3 family" . Genes Dev . 14 (6): 704–718. doi :10.1101/gad.14.6.704 . PMC 316461 PMID 10733530 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–16903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Bonkobara M, Das A, Takao J, et al. (2003). "Identification of novel genes for secreted and membrane-anchored proteins in human keratinocytes". Br. J. Dermatol . 148 (4): 654–664. doi :10.1046/j.1365-2133.2003.05244.x . PMID 12752121 . S2CID 21635573 . Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6" . Nature . 425 (6960): 805–811. Bibcode :2003Natur.425..805M . doi :10.1038/nature02055 PMID 14574404 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–45. doi :10.1038/ng1285 PMID 14702039 . Ihrie RA, Attardi LD (2004). "Perp-etrating p53-dependent apoptosis" . Cell Cycle . 3 (3): 267–269. doi :10.4161/cc.3.3.722 PMID 14726658 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–2127. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries" . DNA Res . 12 (2): 117–126. doi :10.1093/dnares/12.2.117 PMID 16303743 .
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