Pinin
Protein-coding gene in the species Homo sapiens
Pinin is a protein that in humans is encoded by the PNN gene .[5] [6]
Interactions
Pinin has been shown to interact with Keratin 8 ,[7] Keratin 18 ,[7] Keratin 19 ,[7] CTBP1 ,[8] RNPS1 ,[9] [10] PRPF4B ,[11] SFRS4 ,[12] PPIG ,[13] SRRM2 [12] and SFRS18 .[12]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000100941 - Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020994 - Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Ouyang P, Sugrue SP (January 1997). "Characterization of pinin, a novel protein associated with the desmosome-intermediate filament complex" . J Cell Biol . 135 (4): 1027–42. doi :10.1083/jcb.135.4.1027 . PMC 2133386 . PMID 8922384 .
^ "Entrez Gene: PNN pinin, desmosome associated protein" .
^ a b c Shi, J; Sugrue S P (May 2000). "Dissection of protein linkage between keratins and pinin, a protein with dual location at desmosome-intermediate filament complex and in the nucleus" . J. Biol. Chem . 275 (20): 14910–5. doi :10.1074/jbc.275.20.14910 . ISSN 0021-9258 . PMID 10809736 .
^ Alpatov, Roman; Munguba Gustavo Costa; Caton Paul; Joo Jeong Hoon; Shi Yang; Shi Yujiang; Hunt Marguerite E; Sugrue Stephen P (December 2004). "Nuclear speckle-associated protein Pnn/DRS binds to the transcriptional corepressor CtBP and relieves CtBP-mediated repression of the E-cadherin gene" . Mol. Cell. Biol . 24 (23): 10223–35. doi :10.1128/MCB.24.23.10223-10235.2004 . ISSN 0270-7306 . PMC 529029 . PMID 15542832 .
^ Ewing, Rob M; Chu Peter; Elisma Fred; Li Hongyan; Taylor Paul; Climie Shane; McBroom-Cerajewski Linda; Robinson Mark D; O'Connor Liam; Li Michael; Taylor Rod; Dharsee Moyez; Ho Yuen; Heilbut Adrian; Moore Lynda; Zhang Shudong; Ornatsky Olga; Bukhman Yury V; Ethier Martin; Sheng Yinglun; Vasilescu Julian; Abu-Farha Mohamed; Lambert Jean-Philippe; Duewel Henry S; Stewart Ian I; Kuehl Bonnie; Hogue Kelly; Colwill Karen; Gladwish Katharine; Muskat Brenda; Kinach Robert; Adams Sally-Lin; Moran Michael F; Morin Gregg B; Topaloglou Thodoros; Figeys Daniel (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry" . Mol. Syst. Biol . 3 (1): 89. doi :10.1038/msb4100134 . PMC 1847948 . PMID 17353931 .
^ Li, Chin; Lin Ru-Inn; Lai Ming-Chih; Ouyang Pin; Tarn Woan-Yuh (October 2003). "Nuclear Pnn/DRS protein binds to spliced mRNPs and participates in mRNA processing and export via interaction with RNPS1" . Mol. Cell. Biol . 23 (20): 7363–76. doi :10.1128/MCB.23.20.7363-7376.2003 . ISSN 0270-7306 . PMC 230327 . PMID 14517304 .
^ Dellaire, Graham; Makarov Evgeny M; Cowger Jeff J M; Longman Dasa; Sutherland Heidi G E; Lührmann Reinhard; Torchia Joseph; Bickmore Wendy A (July 2002). "Mammalian PRP4 kinase copurifies and interacts with components of both the U5 snRNP and the N-CoR deacetylase complexes" . Mol. Cell. Biol . 22 (14): 5141–56. doi :10.1128/MCB.22.14.5141-5156.2002 . ISSN 0270-7306 . PMC 139773 . PMID 12077342 .
^ a b c Zimowska, Grazyna; Shi Jia; Munguba Gustavo; Jackson Moira R; Alpatov Roman; Simmons Matthew N; Shi Yujiang; Sugrue Stephen P (November 2003). "Pinin/DRS/memA interacts with SRp75, SRm300 and SRrp130 in corneal epithelial cells" . Invest. Ophthalmol. Vis. Sci . 44 (11): 4715–23. doi :10.1167/iovs.03-0240 . ISSN 0146-0404 . PMID 14578391 .
^ Lin, Chun Lun; Leu Steve; Lu Ming Chu; Ouyang Pin (August 2004). "Over-expression of SR-cyclophilin, an interaction partner of nuclear pinin, releases SR family splicing factors from nuclear speckles". Biochem. Biophys. Res. Commun . 321 (3): 638–47. doi :10.1016/j.bbrc.2004.07.013 . ISSN 0006-291X . PMID 15358154 .
Further reading
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene . 138 (1–2): 171–4. doi :10.1016/0378-1119(94)90802-8 . PMID 8125298 .
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene . 200 (1–2): 149–56. doi :10.1016/S0378-1119(97)00411-3 . PMID 9373149 .
Brandner JM, Reidenbach S, Franke WW (1998). "Evidence that "pinin", reportedly a differentiation-specific desmosomal protein, is actually a widespread nuclear protein". Differentiation . 62 (3): 119–27. doi :10.1046/j.1432-0436.1997.6230119.x . PMID 9447706 .
Degen WG, Agterbos MA, Muyrers JP, et al. (1999). "memA/DRS, a putative mediator of multiprotein complexes, is overexpressed in the metastasizing human melanoma cell lines BLM and MV3". Biochim. Biophys. Acta . 1444 (3): 384–94. doi :10.1016/s0167-4781(99)00012-3 . PMID 10095061 .
Ouyang P (1999). "Antibodies differentiate desmosome-form and nucleus-form pinin: evidence that pinin is a moonlighting protein with dual location at the desmosome and within the nucleus". Biochem. Biophys. Res. Commun . 263 (1): 192–200. doi :10.1006/bbrc.1999.1353 . PMID 10486276 .
Shi Y, Ouyang P, Sugrue SP (2000). "Characterization of the gene encoding pinin/DRS/memA and evidence for its potential tumor suppressor function" . Oncogene . 19 (2): 289–97. doi :10.1038/sj.onc.1203328 . PMID 10645008 .
Shi J, Sugrue SP (2000). "Dissection of protein linkage between keratins and pinin, a protein with dual location at desmosome-intermediate filament complex and in the nucleus" . J. Biol. Chem . 275 (20): 14910–5. doi :10.1074/jbc.275.20.14910 . PMID 10809736 .
Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning" . Proc. Natl. Acad. Sci. U.S.A . 97 (17): 9543–8. Bibcode :2000PNAS...97.9543H . doi :10.1073/pnas.160270997 . PMC 16901 . PMID 10931946 .
Jurica MS, Licklider LJ, Gygi SR, et al. (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis" . RNA . 8 (4): 426–39. doi :10.1017/S1355838202021088 . PMC 1370266 . PMID 11991638 .
Wang P, Lou PJ, Leu S, Ouyang P (2002). "Modulation of alternative pre-mRNA splicing in vivo by pinin". Biochem. Biophys. Res. Commun . 294 (2): 448–55. doi :10.1016/S0006-291X(02)00495-3 . PMID 12051732 .
Dellaire G, Makarov EM, Cowger JJ, et al. (2002). "Mammalian PRP4 kinase copurifies and interacts with components of both the U5 snRNP and the N-CoR deacetylase complexes" . Mol. Cell. Biol . 22 (14): 5141–56. doi :10.1128/MCB.22.14.5141-5156.2002 . PMC 139773 . PMID 12077342 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 . PMC 139241 . PMID 12477932 .
Chang WL, Lee DC, Leu S, et al. (2003). "Molecular characterization of a novel nucleolar protein, pNO40". Biochem. Biophys. Res. Commun . 307 (3): 569–77. doi :10.1016/S0006-291X(03)01208-7 . PMID 12893261 .
Li C, Lin RI, Lai MC, et al. (2003). "Nuclear Pnn/DRS protein binds to spliced mRNPs and participates in mRNA processing and export via interaction with RNPS1" . Mol. Cell. Biol . 23 (20): 7363–76. doi :10.1128/MCB.23.20.7363-7376.2003 . PMC 230327 . PMID 14517304 .
Zimowska G, Shi J, Munguba G, et al. (2003). "Pinin/DRS/memA interacts with SRp75, SRm300 and SRrp130 in corneal epithelial cells" . Invest. Ophthalmol. Vis. Sci . 44 (11): 4715–23. doi :10.1167/iovs.03-0240 . PMID 14578391 .
Sakashita E, Tatsumi S, Werner D, et al. (2004). "Human RNPS1 and its associated factors: a versatile alternative pre-mRNA splicing regulator in vivo" . Mol. Cell. Biol . 24 (3): 1174–87. doi :10.1128/MCB.24.3.1174-1187.2004 . PMC 321435 . PMID 14729963 .
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins" . Proc. Natl. Acad. Sci. U.S.A . 101 (33): 12130–5. Bibcode :2004PNAS..10112130B . doi :10.1073/pnas.0404720101 . PMC 514446 . PMID 15302935 .
Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization" . Curr. Biol . 14 (16): 1436–50. doi :10.1016/j.cub.2004.07.051 . PMID 15324660 . S2CID 2371325 .
Lin CL, Leu S, Lu MC, Ouyang P (2004). "Over-expression of SR-cyclophilin, an interaction partner of nuclear pinin, releases SR family splicing factors from nuclear speckles". Biochem. Biophys. Res. Commun . 321 (3): 638–47. doi :10.1016/j.bbrc.2004.07.013 . PMID 15358154 .
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