PyBOP
Names | |
---|---|
IUPAC name
(Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate
| |
Other names
PyBOP
| |
Identifiers | |
3D model (JSmol)
|
|
ChemSpider | |
ECHA InfoCard | 100.125.168 |
PubChem CID
|
|
UNII | |
CompTox Dashboard (EPA)
|
|
| |
| |
Properties | |
C18H28F6N6OP2 | |
Molar mass | 520.401 g·mol−1 |
Appearance | White crystals |
Melting point | 150 °C (302 °F; 423 K) |
Hazards | |
Occupational safety and health (OHS/OSH): | |
Main hazards
|
Irritant |
GHS labelling:[1][2][citation needed] | |
Warning | |
H315, H319, H335 | |
P261, P305+P351+P338 | |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
|
PyBOP (benzotriazol-1-yloxytripyrrolidinophosphonium hexafluorophosphate) is a peptide coupling reagent used in solid phase peptide synthesis. It is used as a substitute for the BOP reagent - avoiding the formation of the carcinogenic waste product HMPA.[3]
See also
- BOP reagent
- DEPBT, a related reagent that contains no phosphorus-nitrogen bonds
- HATU
- HBTU
References
- ^ Sigma-Aldrich Co., product no. {id}.
- ^ GHS: Sigma-Aldrich377848
- ^ Coste, J.; Le-Nguyen, D.; Castro, B. (1990). "PyBOP®: A new peptide coupling reagent devoid of toxic by-product". Tetrahedron Letters. 31 (2): 205. doi:10.1016/S0040-4039(00)94371-5.