TSPAN3

TSPAN3
Identifiers
Aliases	TSPAN3, TM4-A, TM4SF8, TSPAN-3, tetraspanin 3
External IDs	OMIM: 613134; MGI: 1928098; HomoloGene: 21168; GeneCards: TSPAN3; OMA:TSPAN3 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	77,083,984 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	56,072,761 bp
RNA expression pattern
	Top expressed in
	bronchial epithelial cell; ; mucosa of sigmoid colon; ; ventricular zone; ; rectum; ; corpus epididymis; ; beta cell; ; caput epididymis; ; palpebral conjunctiva; ; right uterine tube; ; external globus pallidus;
	Top expressed in
	vestibular sensory epithelium; ; Epithelium of choroid plexus; ; nucleus of stria terminalis; ; central gray substance of midbrain; ; ventral tegmental area; ; right kidney; ; left colon; ; saccule; ; dorsomedial hypothalamic nucleus; ; superior colliculus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	molecular function;
Cellular component	integral component of membrane; integral component of plasma membrane; extracellular exosome; membrane;
Biological process	cell surface receptor signaling pathway; biological process;
	Sources:Amigo / QuickGO
Orthologs
	10099
	56434
	ENSG00000140391
	ENSMUSG00000032324
	O60637
	Q9QY33
	NM_198902; NM_001168412; NM_005724
	NM_019793
	NP_001161884; NP_005715; NP_944492
	NP_062767
	Wikidata
View/Edit Human	View/Edit Mouse

Tetraspanin-3 is a protein that in humans is encoded by the TSPAN3 gene.^[5]

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains.

The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The use of alternate polyadenylation sites has been found for this gene. Two alternative transcripts encoding different isoforms have been described.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000140391 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032324 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: TSPAN3 tetraspanin 3".

External links

TSPAN3 human gene location in the UCSC Genome Browser.
TSPAN3 human gene details in the UCSC Genome Browser.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000140391 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032324 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: TSPAN3 tetraspanin 3".

[1]

[2]

[3]

[4]

[5]

v t e Protein: cell membrane proteins (other than Cell surface receptor, enzymes, and cytoskeleton)
Arrestin	SAG ARRB1 ARRB2 ARR3
Membrane-spanning 4A	MS4A1 MS4A2 MS4A3 MS4A4A MS4A4E MS4A5 MS4A6A MS4A6E MS4A7 MS4A8B MS4A9 MS4A10 MS4A12 MS4A13 MS4A14 MS4A15 MS4A18
Myelin	Myelin basic protein PMP2 Myelin proteolipid protein PLP1 Myelin oligodendrocyte glycoprotein Myelin-associated glycoprotein Myelin protein zero
Pulmonary surfactant	Pulmonary surfactant-associated protein B Pulmonary surfactant-associated protein C
Tetraspanin	TSPAN1 TSPAN2 TSPAN3 TSPAN4 TSPAN5 TSPAN6 TSPAN7 TSPAN8 TSPAN9 TSPAN10 TSPAN11 TSPAN12 TSPAN13 TSPAN14 TSPAN15 TSPAN16 TSPAN17 TSPAN18 TSPAN19 TSPAN20 TSPAN21 TSPAN22 TSPAN23 TSPAN24 TSPAN25 TSPAN26 TSPAN27 TSPAN28 TSPAN29 TSPAN30 TSPAN31 TSPAN32 TSPAN33 TSPAN34
Other/ungrouped	Calnexin LDL-receptor-related protein-associated protein Neurofibromin 2 Presenilin PSEN1 PSEN2 HFE Phospholipid transfer proteins Dysferlin STRC OTOF
see also other cell membrane protein disorders

TSPAN3

References

Further reading

External links