1965. aastal asutas ta koos Syd Barretti, Richard Wrighti ja Roger Watersiga ansambli Sigma 6, millest hiljem kujunes Pink Floyd. Juba nende esimest albumit "The Piper at the Gates of Dawn" saatis edu.
Ta on koos Pink Floydi liikmetega paljude nende lugude autoriks, näiteks "Echoes", "Time", "Careful with That Axe, Eugene" ja "One of These Days". 2018. aastal moodustas ta uue ansambli Nick Mason's Saucerful of Secrets, et esitada Pink Floydi varase perioodi muusikat.
The Committee · Tonite Let's All Make Love in London · More · Zabriskie Point · Obscured by Clouds
Kontsertalbumid
Ummagumma· Is There Anybody Out There? The Wall Live 1980–81 · Delicate Sound of Thunder · Pulse
Kogumikalbumid
The Best of the Pink Floyd · Relics · A Nice Pair · Masters of Rock · A Collection of Great Dance Songs · Works · Shine On · (The Early Singles) · 1967: The First Three Singles · Echoes: The Best of Pink Floyd · Oh, by the Way
Filmid
Live at Pompeii · The Wall · Delicate Sound of Thunder · La Carrera Panamericana · Pulse · The Pink Floyd and Syd Barrett Story · The Making of The Dark Side of the Moon · London '66-'67