RBM3

RBM3
معین‌کننده‌ها
نام‌های دیگر	RBM3, IS1-RNPL, RNPL, RNA binding motif (RNP1, RRM) protein 3, RNA binding motif protein 3
شناسه‌های بیرونی	OMIM: 300027 MGI: 3642874 HomoloGene: 31404 GeneCards: RBM3
موقعیت ژن (انسان)
کروموزوم	کروموزوم X (انسان)
پایان	48,581,162 bp
الگوی گسترش RNA
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• GO:0001948، GO:0016582 پیوند پروتئینی; • nucleic acid binding; • RNA binding; • mRNA 3'-UTR binding; • poly(U) RNA binding; • translation repressor activity; • ribosomal large subunit binding; • small ribosomal subunit rRNA binding;
ترکیبات سلولی	• سیتوپلاسم; • large ribosomal subunit; • دندریت; • cell projection; • هستک; • هسته یاخته; • نوکلئوپلاسم; • spliceosomal complex; • ribonucleoprotein complex;
فرایند زیستی	• GO:0033168، GO:0036404، GO:1902360 RNA processing; • regulation of translation; • positive regulation of translation; • response to cold; • negative regulation of translation; • positive regulation of mRNA splicing, via spliceosome;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	5935
	100043257
	ENSG00000102317
	ن/م
	P98179
	ن/م
	NM_001017431، NM_006743 NM_001017430، NM_001017431، NM_006743
	XM_036156140
	XP_024308181، XP_024308182 NP_006734، XP_024308181، XP_024308182
	ن/م
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

پروتئین فرضی ۳ اتصال به آران‌ای (انگلیسی: Putative RNA-binding protein 3) یک پروتئین است که در انسان توسط ژن «RBM3» کُدگذاری می‌شود.^[۴]^[۵]

اهمیت بالینی

این پروتئین یک پروتوآنکوژن است که با رشد تومور و احتمال متاستاز بیشتر آن مرتبط است و یک زیست‌نشانگر بالقوه سرطان محسوب می‌شود.^[۶] بر اساس داده‌های بقای بیمار، سطوح بالای پروتئین RBM3 در سلول‌های تومور، یک زیست‌نشانگر پیش‌آگهی مطلوب در سرطان روده بزرگ است.^[۷]

منابع

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCh38: Ensembl release 89: ENSG00000102317 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Derry JM, Kerns JA, Francke U (December 1995). "RBM3, a novel human gene in Xp11.23 with a putative RNA-binding domain". Human Molecular Genetics. 4 (12): 2307–11. doi:10.1093/hmg/4.12.2307. PMID 8634703.
↑ "Entrez Gene: RBM3 RNA binding motif (RNP1, RRM) protein 3".
↑ Zhou RB, Lu XL, Zhang CY, Yin DC (March 2017). "RNA binding motif protein 3: a potential biomarker in cancer and therapeutic target in neuroprotection". Oncotarget. 8 (13): 22235–22250. doi:10.18632/oncotarget.14755. PMC 5400660. PMID 28118608.
↑ "Expression of RBM3 in cancer - Summary". The Human Protein Atlas.

برای مطالعهٔ بیشتر

Danno S, Nishiyama H, Higashitsuji H, Yokoi H, Xue JH, Itoh K, Matsuda T, Fujita J (July 1997). "Increased transcript level of RBM3, a member of the glycine-rich RNA-binding protein family, in human cells in response to cold stress". Biochemical and Biophysical Research Communications. 236 (3): 804–7. doi:10.1006/bbrc.1997.7059. PMID 9245737.
Chappell SA, Mauro VP (September 2003). "The internal ribosome entry site (IRES) contained within the RNA-binding motif protein 3 (Rbm3) mRNA is composed of functionally distinct elements". The Journal of Biological Chemistry. 278 (36): 33793–800. doi:10.1074/jbc.M303495200. PMID 12824175.
Wellmann S, Bührer C, Moderegger E, Zelmer A, Kirschner R, Koehne P, Fujita J, Seeger K (April 2004). "Oxygen-regulated expression of the RNA-binding proteins RBM3 and CIRP by a HIF-1-independent mechanism". Journal of Cell Science. 117 (Pt 9): 1785–94. doi:10.1242/jcs.01026. PMID 15075239.
Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC (May 2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Analytical Chemistry. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
Dellis S, Strickland KC, McCrary WJ, Patel A, Stocum E, Wright CF (November 2004). "Protein interactions among the vaccinia virus late transcription factors". Virology. 329 (2): 328–36. doi:10.1016/j.virol.2004.08.017. hdl:10161/15063. PMID 15518812.
Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (January 2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
Ong SE, Mittler G, Mann M (November 2004). "Identifying and quantifying in vivo methylation sites by heavy methyl SILAC". Nature Methods. 1 (2): 119–26. doi:10.1038/nmeth715. PMID 15782174. S2CID 6654604.
Martínez-Arribas F, Agudo D, Pollán M, Gómez-Esquer F, Díaz-Gil G, Lucas R, Schneider J (April 2006). "Positive correlation between the expression of X-chromosome RBM genes (RBMX, RBM3, RBM10) and the proapoptotic Bax gene in human breast cancer". Journal of Cellular Biochemistry. 97 (6): 1275–82. doi:10.1002/jcb.20725. PMID 16552754. S2CID 9804734.

[refGRCh38Ensembl-1] ۱٫۰ ^۱٫۱ ^۱٫۲ GRCh38: Ensembl release 89: ENSG00000102317 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8634703-4] Derry JM, Kerns JA, Francke U (December 1995). "RBM3, a novel human gene in Xp11.23 with a putative RNA-binding domain". Human Molecular Genetics. 4 (12): 2307–11. doi:10.1093/hmg/4.12.2307. PMID 8634703.

[entrez-5] "Entrez Gene: RBM3 RNA binding motif (RNP1, RRM) protein 3".

[Zhou_2017-6] Zhou RB, Lu XL, Zhang CY, Yin DC (March 2017). "RNA binding motif protein 3: a potential biomarker in cancer and therapeutic target in neuroprotection". Oncotarget. 8 (13): 22235–22250. doi:10.18632/oncotarget.14755. PMC 5400660. PMID 28118608.

[7] "Expression of RBM3 in cancer - Summary". The Human Protein Atlas.

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