Biperidenum

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Biperidenum
Cognitores
ChemSpider 2289
PubChem 2381
DrugBank DB00810
Natura chemica
Biperidenum
Biperidenum
Formula chemica C
21H
29NO
Massa molaris 311.469 g/mol
Natura pharmacologica
Codex ATC N04AA02 (WHO)
Semivita biologica 18—24 h
Metabolismus iecore (hepaticus):
hydroxylatio
Excretio renibus
Ad usum therapeuticum
Applicatio per os., i.m., i.v.

Biperidenum est substantia anticholinergica antagonista receptoriorum muscarinergicorum M1 et M4. Adhibetur morbi Parkinsoniani et perturbationum motuum drogis causa.

Biperidenum in ordinis mundi sanitarii indicem exemplarem medicamentorum essentialium receptum est.

Natura pharmacologica biperideni

Pharmacodynamica

Biperidenum substantia anticholinergica antagonista receptoriorum muscarinergicorum M1 et M4 est[1]. Effectus clinici 6-8 horas remanent.

Maxima hominis dosis diurnalis 16 mg valet. Antidotum physostigminum, parasympathomimeticum indirectum (inhibitione acetylcholini esterasis), est.

Pharmacocinetica

Semivita biologica .[2] 18-24 h est. Excretio maiore in parte per renes est.

Usus medicus

Notae

  1. ↑ Palombo P., Engi S. A., et al. (Feb 2021). "Effects of biperiden (cholinergic muscarinic m1/m4 receptor antagonist) on ethanol conditioned place preference in mice". Neuroscience letters 745: 135551 .
  2. ↑ http://goldbook.iupac.org/B00658.html
  3. ↑ Richardson C., Kelly D. L., Conley R. R. (Aug 2001). "Biperiden for excessive sweating from clozapine". American journal of psychiatry 158 (8): 1329-30 .
  4. ↑ Caflisch C., Figner B., Eich D. (Feb 2003). "Biperiden for excessive sweating from methadone". American journal of psychiatry 160 (2): 386-7 .

Nexus interni

Nexus externi