ഐസോനിയാസിഡ്
ഐസോനിയാസിഡ് Pyridine-4-carbohydrazide
Trade names Hydra, Hyzyd, Isovit, other AHFS/Drugs.com monograph MedlinePlus a682401 Pregnancycategory
US : C (Risk not ruled out) [1]
Routes ofadministration by mouth, intramuscular, intravenous Legal status
Protein binding Very low (0–10%) Metabolism liver; CYP450: 2C19, 3A4 inhibitor Biological half-life 0.5–1.6h (fast acetylators), 2-5h (slow acetylators) Excretion urine (primarily), feces
CAS Number 54-85-3 Y ATC code J04AC01 (WHO ) PubChem CID 3767 DrugBank DB00951 Y ChemSpider 3635 Y UNII V83O1VOZ8L Y KEGG D00346 Y ChEBI CHEBI:6030 Y ChEMBL CHEMBL64 Y NIAID ChemDB 007657 Synonyms isonicotinic acid hydrazide, isonicotinyl hydrazine, INHA Formula C 6 H 7 N 3 O Molar mass 137.139 g/mol
InChI=1S/C6H7N3O/c7-9-6(10)5-1-3-8-4-2-5/h1-4H,7H2,(H,9,10)
Y Key:QRXWMOHMRWLFEY-UHFFFAOYSA-N
Y
ക്ഷയരോഗത്തിന് നിലവിലുള്ള മരുന്നുകളിൽ ഒന്നാണ് ഐസോനിയാസിഡ് .[2] ക്ഷയത്തിന് ഇത് റിഫാംപിസിൻ, പൈറാസിനമൈഡ്, സ്ട്രെപ്റ്റോമൈസിൻ അല്ലെങ്കിൽ എത്താംബ്യൂട്ടോൾ എന്നിവയ്ക്കൊപ്പം ഉപയോഗിക്കുന്നു.
അവലംബം
↑ "Isoniazid". The American Society of Health-System Pharmacists. Archived from the original on 20 December 2016. Retrieved 8 December 2016.
↑ "Isoniazid". The American Society of Health-System Pharmacists. Archived from the original on 20 December 2016. Retrieved 8 December 2016.
ബാഹ്യ ലിങ്കുകൾ
See Chapter 6, Treatment of LTBI Regimens – Isoniazid :: See Chapter 7 – Treatment of TB Disease Monitoring – Adverse Reactions to First-line TB Drugs – Isoniazid :: See Table 5 First-Line Anti-TB Medications
Antimycobacterials, including tuberculosis treatment and leprostatic agents (J04)
Nucleic acid inhibitor
Rifamycins/ RNA polymerase inhibitor
Rifampicin#
Rifabutin
Rifapentine
Rifalazil§
Antifolates/DSI
Dapsone#
Acedapsone
Aldesulfone sodium
ASA
4-Aminosalicylic acid # (Calcium aminosalicylate
Sodium aminosalicylate)
Topoisomerase inhibitors/ quinolones
Gatifloxacin
Moxifloxacin
Protein synthesis inhibitor
Aminoglycosides
Amikacin#
Kanamycin#
Streptomycin#
Oxazolidone Polypeptide antibiotics
Cell envelope antibiotic
Peptidoglycan layer
Alanine analogue: Cycloserine#
Arabinogalactan layer
Ethylenediamine/arabinosyltransferase inhibitor: Ethambutol#
Mycolic acid layer
Hydrazides/mycolic acid synth. inhibition: Isoniazid #
Methaniazide
Thiocarbamides: Ethionamide#
Prothionamide
Thiocarlide
Others/unsorted: Thioacetazone (amithiozone)
Other/unknown
Phenazine (Clofazimine)#
Pyrazine (Pyrazinamide# , Morinamide)
Isoxazole (Terizidone)
Bedaquiline
Metronidazole (delamanid , Pretomanid )
Combinations
Rifampicin/isoniazid/pyrazinamide
# WHO-EM
‡ Withdrawn from market
Clinical trials:
† Phase III
§ Never to phase III
Intracellular
Inhibit peptidoglycan subunit synthesis and transport: NAM synthesis inhibition (Fosfomycin)
DADAL/AR inhibitors (Cycloserine)
bactoprenol inhibitors (Bacitracin)
Glycopeptide
Inhibit PG chain elongation: Vancomycin# (Oritavancin
Telavancin)
Teicoplanin (Dalbavancin)
Ramoplanin
β-lactams/ (inhibit PBP cross-links)
Other
polymyxins/detergent
depolarizing
Hydrolyze NAM-NAG
Tyrothricin
Isoniazid
Teixobactin
# WHO-EM
‡ Withdrawn from market
Clinical trials:
† Phase III
§ Never to phase III
Transporter
GAT
Inhibitors: 4-Aminovaleric acid
β-Alanine
Arecaidine
CI-966
DABA
Deramciclane (EGIS-3886, EGYT-3886)
EF-1502
Gabaculine
Guvacine
Ibotenic acid
Muscimol
Nipecotic acid
NNC 05-2090
NO-711
Riluzole
SKF-89976A
SNAP-5114
TACA
Tiagabine
VIAAT
Inhibitors: β-Alanine
Bafilomycin A1
Chicago sky blue 6B
Evans blue
GABA
Glycine
N-Butyric acid
Nigericin
Nipecotic acid
Valinomycin
Vigabatrin
Enzyme
GAD
Inhibitors: 3-Mercaptopropionic acid
AAOA
L-Allylglycine
Semicarbazide
GABA-T
Inhibitors: 3-Hydrazinopropionic acid
γ-Acetylenic-GABA
AOAA
EOS
Gabaculine
Isoniazid
L-Cycloserine
Phenelzine
PEH
Rosmarinic acid (lemon balm)
Sodium valproate
Valnoctamide
Valproate pivoxil
Valproate semisodium (divalproex sodium)
Valproic acid
Valpromide
Vigabatrin
Activators: 3-Methyl-GABA
Hydrazines
4-PTSC
Acylhydrazine
ADH
Adjudin
Agaritine
Benmoxin
Cadralazine
Carbazide
Carbidopa
Carbohydrazide
Daminozide
Dihydralazine
DNPH
Endralazine
Gyromitrin
HBT
Hydralazine
Hydrazide
Hydrazine
Hydrazone
Iproclozide
Iproniazid
Isocarboxazid
Isoniazid
Mebanazine
Metfendrazine
MMH
Nialamide
Octamoxin
PEH
Phenelzine
Pheniprazine
Phenoxypropazine
Phenylhydrazine
Pildralazine
Pimagedine
Pivalylbenzhydrazine
Procarbazine
Safrazine
Semicarbazide
Semicarbazone
SDMH
Tetrafluorohydrazine
UDMH
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