ଆଲୋସେଟ୍ରନ

ଆଲୋସେଟ୍ରନ
Clinical data
Pronunciation	al oh’ se tron
Trade names	Lotronex
AHFS/Drugs.com	monograph
MedlinePlus	a601230
Pregnancycategory	US: B (No risk in non-human studies) ; ;
Routes ofadministration	By mouth (tablets)
Legal status
Legal status	US: ℞-only ;
Pharmacokinetic data
Bioavailability	50–60%
Protein binding	82%
Metabolism	Liver (including CYP2C9, CYP3A4 and CYP1A2)
Elimination half-life	1.5–1.7 hours
Excretion	Renal 73%, faecal 24%
Identifiers
	IUPAC name 5-methyl-2-[(4-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-1-one;
Chemical and physical data
Formula	C17H18N4O
Molar mass	୨୯୪.୩୬ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Cc1nc[nH]c1CN2CCc4c(C2=O)c3ccccc3n4C;
	InChI InChI=1S/C17H18N4O/c1-11-13(19-10-18-11)9-21-8-7-15-16(17(21)22)12-5-3-4-6-14(12)20(15)2/h3-6,10H,7-9H2,1-2H3,(H,18,19) ; Key:JSWZEAMFRNKZNL-UHFFFAOYSA-N ;
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ଆଲୋସେଟ୍ରନ, ଏକ ବେପାର ନାମ ଲୋଟ୍ରୋନେକ୍ସ, ହେଉଛି ଏକ ଔଷଧ ଯାହା ମହିଳାମାନଙ୍କଠାରେ ଇରିଟେବ୍ଲ ବାୱେଲ ସିଣ୍ଡ୍ରୋମ (ଆଇବିଏସ୍) ଜନିତ ତରଳ ଝାଡ଼ାର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ । ^[୧] ଏହା କେବଳ ଗୁରୁତର ରୋଗରେ ବ୍ୟବହୃତ ହେବା ଉଚିତ, ଯାହା ଅନ୍ୟାନ୍ୟରେ ଚିକିତ୍ସାରେ ଉପଶମ ହୋଇପାରିବେ ନାହିଁ। ^[୨] ଏହା ପାଟିରେ ଦିଆଯାଏ । ^[୨]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ କୋଷ୍ଠକାଠିନ୍ୟ, ପେଟ ଯନ୍ତ୍ରଣା ଏବଂ ଅଇ ହୋଇପାରେ । ^[୩] ଅନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଅନ୍ତନଳୀ ଅବରୋଧ ଏବଂ ଇସକେମିକ୍ କୋଲାଇଟିସ୍ ଅନ୍ତର୍ଭୁକ୍ତ ହୋଇପାରେ । ^[୩] ଗର୍ଭାବସ୍ଥାରେ ସୁରକ୍ଷା ଅସ୍ପଷ୍ଟ ଅଟେ। ^[୩] ଏହା ଏକ ୫-ଏଚଟି<sub id="mwGw">୨</sub> (5-HT <sub id="mwGw">3)</sub> ରିସେପ୍ଟର ବ୍ଲକର୍ । ^[୧]

୧୯୮୭ ମସିହାରେ ଆଲୋସେଟ୍ରନ୍ ପ୍ୟାଟେଣ୍ଟ୍ ହୋଇଥିଲା ଏବଂ ୧୯୯୦ ଦଶକରେ ଡାକ୍ତରୀ ବ୍ୟବହାରରେ ଆସିଥିଲା । ^[୪] ^[୧] କୋଷ୍ଠକାଠିନ୍ୟ କାରଣରୁ ଏହା ୨୦୦୦ରେ ସାମୟିକ ଭାବରେ ପ୍ରତ୍ୟାହାର କରାଯାଇଥିଲା କିନ୍ତୁ ୨୦୦୨ରେ ପୁନଃ ଉତ୍ପାଦିତ ହୋଇଥିଲା । ^[୧] ଏହା ଏକ ସାଧାରଣ ଔଷଧ ଭାବରେ ଉପଲବ୍ଧ । ^[୫] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ମାସକୁ ୨୦୨୨ ସୁଦ୍ଧା ପ୍ରାୟ ୨୪୦ ଡଲାର ଖର୍ଚ୍ଚ ହୋଇଥାଏ ।^[୫]

ଆଧାର

↑ ^୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ "Serotonin 5-HT3 Receptor Antagonists". LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. 2012. Archived from the original on 8 May 2021. Retrieved 14 January 2022.
↑ ^୨.୦ ^୨.୧ "Alosetron Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 25 January 2021. Retrieved 14 January 2022.
↑ ^୩.୦ ^୩.୧ ^୩.୨ "DailyMed - ALOSETRON HYDROCHLORIDE tablet". dailymed.nlm.nih.gov. Archived from the original on 21 April 2021. Retrieved 14 January 2022.
↑ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery (in ଇଂରାଜୀ). John Wiley & Sons. p. 448. ISBN 9783527607495. Archived from the original on 2021-09-30. Retrieved 2021-10-11. {cite book}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
↑ ^୫.୦ ^୫.୧ "Alosetron Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 24 January 2016. Retrieved 14 January 2022.

[Liv2022-1] ୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ "Serotonin 5-HT3 Receptor Antagonists". LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. 2012. Archived from the original on 8 May 2021. Retrieved 14 January 2022.

[AHFS2022-2] ୨.୦ ^୨.୧ "Alosetron Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 25 January 2021. Retrieved 14 January 2022.

[PI2022-3] ୩.୦ ^୩.୧ ^୩.୨ "DailyMed - ALOSETRON HYDROCHLORIDE tablet". dailymed.nlm.nih.gov. Archived from the original on 21 April 2021. Retrieved 14 January 2022.

[4] Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery (in ଇଂରାଜୀ). John Wiley & Sons. p. 448. ISBN 9783527607495. Archived from the original on 2021-09-30. Retrieved 2021-10-11. {cite book}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)

[GX2022-5] ୫.୦ ^୫.୧ "Alosetron Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 24 January 2016. Retrieved 14 January 2022.

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