Acetilornitin transaminaza
| Acetilornitin transaminaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.6.1.11 | ||||||||
| CAS broj | 9030-40-4 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Acetilornitin transaminaza (EC 2.6.1.11, acetilornitinska delta-transaminaza, ACOAT, acetilornitinska 5-aminotransferaza, acetilornitinska aminotransferaza, N-acetilornitinska aminotransferaza, N-acetilornitin-delta-transaminaza, N2-acetilornitin 5-transaminaza, N2-acetil-L-ornitin:2-oksoglutarat aminotransferaza, sukcinilornitinska aminotransferaza, 2-N-acetil-L-ornitin:2-oksoglutarat 5-aminotransferaza) je enzim sa sistematskim imenom N2-acetil-L-ornitin:2-oksoglutarat 5-aminotransferaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- N2-acetil-L-ornitin + 2-oksoglutarat N-acetil-L-glutamat 5-semialdehid + L-glutamat
Ovaj enzim je piridoksal-fosfatni protein. On takođe deluje na L-ornitin i N2-sukcinil-L-ornitin.
Reference
- ↑ Albrecht, A. and Vogel, H.J. (1964). „Acetylornithine δ-transaminase. Partial purification and repression behavior”. J. Biol. Chem. 239: 1872-1876. PMID 14213368.
- ↑ Vogel, H.J. (1953). „Path of ornithine synthesis in Escherichia coli”. Proc. Natl. Acad. Sci. USA 39: 578-583. PMID 16589307.
- ↑ Vander Wauven, C. and Stalon, V. (1985). „Occurrence of succinyl derivatives in the catabolism of arginine in Pseudomonas cepacia”. J. Bacteriol. 164: 882-886. PMID 2865249.
- ↑ Voellmy, R. and Leisinger, T. (1975). „Dual role for N-2-acetylornithine 5-aminotransferase from Pseudomonas aeruginosa in arginine biosynthesis and arginine catabolism”. J. Bacteriol. 122: 799-809. PMID 238949.
Literatura
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.