CCL9

Hemokin (C-C motiv) ligand 9
Identifikatori
Simboli	CCL9; CCF18; MRP-2; Scya9; Scya10; Ccl9
Vanjski ID	MGI: 104533 HomoloGene: 86734
Ontologija gena
Molekularna funkcija	• aktivnost protein kinaza; • aktivnost prenosa signala; • hemokinska aktivnost;
Celularna komponenta	• ekstracelularni region; • ekstracelularni prostor; • membrana;
Biološki proces	• proteinska aminokiselinska fosforilacija; • ćelijska homeostaza kalcijum jona; • anti-apoptoza; • hemotaksa; • inflamatorni odgovor; • humoralni imunski odgovor; • ćelijska adhezija; • G-protein signalizacija, spregnuta sa ciklikličnim nukleotidnim drugim glasnikom; • JAK-STAT kaskada; • interćelijska signalizacija; • morfogeneza organa; • replikacija viralnog genoma;
Ortolozi

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CCL9, hemokin (C-C motiv) ligand 9, je mali citokin iz CC hemokin familije. On se naziva makrofagni inflamatorni protein-1 gama (MIP-1γ), protein-2 koji je sličan macrofagnom inflamatornom proteinu (MRP-2) i CCF18. Bio je opisan kod glodara. CCL9 je ranije imao oznaku CCL10. Ta oznaka se više ne koristi. On se izlučuje iz folikl-asociranog epitelijuma (FAE). CCL9 privlači dendritske ćelije koje poseduju CD11b molekule na ćelijskoj površini i hemokin receptor CCR1.^[1] CCL9 može da aktivira osteoklaste putem njegovog receptora CCR1 (koji je najobilniji hemokin receptor na osteoklastima) što ide u podršku važnosti CCL9 uloge u resoprciji kostiju.^[2] CCL9 je konstitutivno izražen u makrofagama i mijeloidnim ćelijama.^[3]^[4] Gen za CCL9 je lociran na hromozomu 11 kod miševa.^[4]^[5]

Reference

↑ Zhao X, Sato A, Dela Cruz C, Linehan M, Luegering A, Kucharzik T, Shirakawa A, Marquez G, Farber J, Williams I, Iwasaki A (2003). „CCL9 is secreted by the follicle-associated epithelium and recruits dome region Peyer's patch CD11b+ dendritic cells”. J Immunol 171 (6): 2797–803. PMID 12960300.
↑ Lean J, Murphy C, Fuller K, Chambers T (2002). „CCL9/MIP-1gamma and its receptor CCR1 are the major chemokine ligand/receptor species expressed by osteoclasts”. J Cell Biochem 87 (4): 386–93. DOI:10.1002/jcb.10319. PMID 12397598.
↑ Youn B, Jang I, Broxmeyer H, Cooper S, Jenkins N, Gilbert D, Copeland N, Elick T, Fraser M, Kwon B (1995). „A novel chemokine, macrophage inflammatory protein-related protein-2, inhibits colony formation of bone marrow myeloid progenitors”. J Immunol 155 (5): 2661–7. PMID 7650394.
↑ ^4,0 ^4,1 Hara T, Bacon K, Cho L, Yoshimura A, Morikawa Y, Copeland N, Gilbert D, Jenkins N, Schall T, Miyajima A (1995). „Molecular cloning and functional characterization of a novel member of the C-C chemokine family”. J Immunol 155 (11): 5352–8. PMID 7594550.
↑ Mire-Sluis, Anthony R.; Thorpe, Robin, ur. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5.

[1] Zhao X, Sato A, Dela Cruz C, Linehan M, Luegering A, Kucharzik T, Shirakawa A, Marquez G, Farber J, Williams I, Iwasaki A (2003). „CCL9 is secreted by the follicle-associated epithelium and recruits dome region Peyer's patch CD11b+ dendritic cells”. J Immunol 171 (6): 2797–803. PMID 12960300.

[2] Lean J, Murphy C, Fuller K, Chambers T (2002). „CCL9/MIP-1gamma and its receptor CCR1 are the major chemokine ligand/receptor species expressed by osteoclasts”. J Cell Biochem 87 (4): 386–93. DOI:10.1002/jcb.10319. PMID 12397598.

[3] Youn B, Jang I, Broxmeyer H, Cooper S, Jenkins N, Gilbert D, Copeland N, Elick T, Fraser M, Kwon B (1995). „A novel chemokine, macrophage inflammatory protein-related protein-2, inhibits colony formation of bone marrow myeloid progenitors”. J Immunol 155 (5): 2661–7. PMID 7650394.

[hara-4] 4,0 ^4,1 Hara T, Bacon K, Cho L, Yoshimura A, Morikawa Y, Copeland N, Gilbert D, Jenkins N, Schall T, Miyajima A (1995). „Molecular cloning and functional characterization of a novel member of the C-C chemokine family”. J Immunol 155 (11): 5352–8. PMID 7594550.

[5] Mire-Sluis, Anthony R.; Thorpe, Robin, ur. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5.

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