EGLU

EGLU
(IUPAC) ime
(2S)-2-amino-2-etilpentandionska kiselina
Klinički podaci
Identifikatori
ATC kod nije dodeljen
PubChem[1][2] 5311079
Hemijski podaci
Formula C7H13NO4 
Mol. masa 175,182 g/mol
Farmakoinformacioni podaci
Trudnoća ?
Pravni status

(2S)-α-Etilglutaminska kiselina (EGLU) je lek koji se koristi u neurološkim istraživanjima. On je bio jedno od prvih jedinjenja za koja je utvrđeno da deluju kao selektivni antagonisti za grupu II metabotropnih glutamatnih receptora (mGluR2/3), tako da je bio koristan u karakterizaciji i istraživanju ove receptorske familije.[3][4][5][6][7][8][9]

Reference

  1. ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. ↑ Jane, DE; Thomas, NK; Tse, HW; Watkins, JC (1996). „Potent antagonists at the L-AP4- and (1S,3S)-ACPD-sensitive presynaptic metabotropic glutamate receptors in the neonatal rat spinal cord”. Neuropharmacology 35 (8): 1029–35. DOI:10.1016/S0028-3908(96)00048-2. PMID 9121605. 
  4. ↑ Huang, L; Rowan, MJ; Anwyl, R (1999). „Induction of long-lasting depression by (+)-alpha-methyl-4-carboxyphenylglycine and other group II mGlu receptor ligands in the dentate gyrus of the hippocampus in vitro”. European Journal of Pharmacology 366 (2–3): 151–8. DOI:10.1016/S0014-2999(98)00918-2. PMID 10082195. 
  5. ↑ Palazzo, E; Marabese, I; De Novellis, V; Oliva, P; Rossi, F; Berrino, L; Rossi, F; Maione, S (2001). „Metabotropic and NMDA glutamate receptors participate in the cannabinoid-induced antinociception”. Neuropharmacology 40 (3): 319–26. DOI:10.1016/S0028-3908(00)00160-X. PMID 11166324. 
  6. ↑ Iserhot, C; Gebhardt, C; Schmitz, D; Heinemann, U (2004). „Glutamate transporters and metabotropic receptors regulate excitatory neurotransmission in the medial entorhinal cortex of the rat”. Brain Research 1027 (1–2): 151–60. DOI:10.1016/j.brainres.2004.08.052. PMID 15494166. 
  7. ↑ Cahusac, PM; Wan, H (2007). „Group II metabotropic glutamate receptors reduce excitatory but not inhibitory neurotransmission in rat barrel cortex in vivo”. Neuroscience 146 (1): 202–12. DOI:10.1016/j.neuroscience.2007.01.049. PMID 17346894. 
  8. ↑ Kim, WY; Vezina, P; Kim, JH (2008). „Blockade of group II, but not group I, mGluRs in the rat nucleus accumbens inhibits the expression of conditioned hyperactivity in an amphetamine-associated environment”. Behavioural Brain Research 191 (1): 62–6. DOI:10.1016/j.bbr.2008.03.010. PMID 18433894. 
  9. ↑ Altinbilek, B; Manahan-Vaughan, D (2009). „A specific role for group II metabotropic glutamate receptors in hippocampal long-term depression and spatial memory”. Neuroscience 158 (1): 149–58. DOI:10.1016/j.neuroscience.2008.07.045. PMID 18722513. 

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