GR-89696 je lek koji deluje kao visoko selektivni κ-opioidniagonist.[3] On pokazuje selektivno dejstvo u različitim životinjskim modelima, i smatra se da je on selektivan za κ2 tip receptora.[4][5][6] Nedavne studije indiciraju da su GR-89696 i srodni κ2-selektivni agonisti korisni u sprečavanju svrabeža koji je uobičajena nuspojava konvencionalnih opioidnihanalgetika, bez dodatnih nuspojava ne-selektivnih kapa agonista.[7]
↑Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑Naylor A, Judd DB, Lloyd JE, Scopes DI, Hayes AG, Birch PJ (July 1993). „A potent new class of kappa-receptor agonist: 4-substituted 1-(arylacetyl)-2-[(dialkylamino)methyl]piperazines”. Journal of Medicinal Chemistry36 (15): 2075–83. PMID8393489.
↑Ho J, Mannes AJ, Dubner R, Caudle RM (April 1997). „Putative kappa-2 opioid agonists are antihyperalgesic in a rat model of inflammation”. The Journal of Pharmacology and Experimental Therapeutics281 (1): 136–41. PMID9103490.
↑Butelman ER, Ko MC, Traynor JR, Vivian JA, Kreek MJ, Woods JH (September 2001). „GR89,696: a potent kappa-opioid agonist with subtype selectivity in rhesus monkeys”. The Journal of Pharmacology and Experimental Therapeutics298 (3): 1049–59. PMID11504802.