IkB kinaza
| IkB kinaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.7.11.10 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
IkB kinaza (EC 2.7.11.10, CHUK, IKBKA, IKBKB, IKK, IKK-1, IKK-2, inhibitor of NFkapaB kinaza, inhibitor NF-kappaB kinaza, STK12, TANK-vezujući kinaza 1, TBK1) je enzim sa sistematskim imenom ATP:(IkappaB protein) fosfotransferaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
Ovaj enzim fosforiliše IkapaB proteine na specifičnim serinskim ostacima.
Reference
- ↑ Regnier, C.H., Song, H.Y., Gao, X., Goeddel, D.V., Cao, Z. and Rothe, M. (1997). „Identification and characterization of an IkappaB kinase”. Cell 90: 373-383. PMID 9244310.
- ↑ Mercurio, F., Zhu, H., Murray, B.W., Shevchenko, A., Bennett, B.L., Li, J., Young, D.B., Barbosa, M., Mann, M., Manning, A. and Rao, A. (1997). „IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation”. Science 278: 860-866. PMID 9346484.
- ↑ Zandi, E., Rothwarf, D.M., Delhase, M., Hayakawa, M. and Karin, M. (1997). „The IkappaB kinase complex (IKK) contains two kinase subunits, IKKα and IKKβ, necessary for IkappaB phosphorylation and NF-kappaB activation”. Cell 91: 243-252. PMID 9346241.
- ↑ Viatour, P., Merville, M.P., Bours, V. and Chariot, A. (2005). „Phosphorylation of NF-kappaB and IkappaB proteins: implications in cancer and inflammation”. Trends Biochem. Sci. 30: 43-52. PMID 15653325.
Literatura
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.