Indijum (111In) kapromab pendetid
| Klinički podaci | |
|---|---|
| AHFS/Drugs.com | (111In) capromab pendetide.html Monografija |
| Identifikatori | |
| CAS broj | 145464-28-4 |
| ATC kod | V09IB04 |
| DrugBank | DB00089 |
| ChEMBL[1] | CHEMBL1201579 
|
| Hemijski podaci | |
| Formula | ? |
| Fizički podaci | |
| Tačka topljenja | 61 °C (142 °F) |
| Farmakoinformacioni podaci | |
| Trudnoća | ? |
| Pravni status | |
Indijum (111In) kapromab pendetid (Prostascint) se koristi pri snimanju raka prostate.[2] Kapromab je monoklonalno antitelo miša koje prepoznaje membranski antigen specifičan za prostatu (PSMA) iz ćelija raka prostate i normalnog prostatnog tkiva. On je vezan za pendetid, DTPA derivat.[3] Pendetid deluje kao helatni agens za radionuklid indijum-111. Nakon intravenozne injekcije, snimanje se vrši koristeći kompjuterizovanu tomografiju emisije pojedinačnog fotona (SPECT).[2][4][5]
Reference
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.
- ↑ 2,0 2,1 Manyak, M. J. (2008). „Indium-111 capromab pendetide in the management of recurrent prostate cancer”. Expert Review of Anticancer Therapy 8 (2): 175–122. DOI:10.1586/14737140.8.2.175. PMID 18279057.
- ↑ WHO Drug Information
- ↑ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035-41. DOI:10.1093/nar/gkq1126. PMC 3013709. PMID 21059682.
- ↑ David S. Wishart, Craig Knox, An Chi Guo, Dean Cheng, Savita Shrivastava, Dan Tzur, Bijaya Gautam, and Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Res 36 (Database issue): D901-6. DOI:10.1093/nar/gkm958. PMC 2238889. PMID 18048412.
Literatura
- Hardman JG, Limbird LE, Gilman AG. (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10 izd.). New York: McGraw-Hill. DOI:10.1036/0071422803. ISBN 0-07-135469-7.
- Thomas L. Lemke, David A. Williams, ur. (2007). Foye's Principles of Medicinal Chemistry (6 izd.). Baltimore: Lippincott Willams & Wilkins. ISBN 0-7817-6879-9.
