Karnitin O-palmitoiltransferaza
| Karnitin O-palmitoiltransferaza | |||||||||
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| Identifikatori | |||||||||
| EC broj | 2.3.1.21 | ||||||||
| CAS broj | 9068-41-1 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Karnitin O-palmitoiltransferaza (EC 2.3.1.21, CPT, CPTo, spoljašna malonil-KoA inhibitabilna karnitinska palmitoiltransferaza, CPTi, CPT I (spoljašnja membranska karnitin palmitoilna transferaza), karnitinska palmitoiltransferaza I, karnitinska palmitoiltransferaza II, CPT-A, CPT-B, acilkarnitinska transferaza, karnitinska palmitoiltransferaza, karnitinska palmitoiltransferaza-A, L-karnitinska palmitoiltransferaza, palmitoilkarnitinska transferaza) je enzim sa sistematskim imenom palmitoil-KoA:L-karnitin O-palmitoiltransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- palmitoil-KoA + L-karnitin KoA + L-palmitoilkarnitin
Ovaj enzim ima široku specifičnost za acil grupe, u opsegu C8 do C18. Optimalni supstrat je palmitoil-KoA.
Reference
- ↑ Derrick, J.P., Tubbs, P.K. and Ramsay, R.R. (1986). „Purification and properties of an easily solubilized L-carnitine palmitoyltransferase from beef-liver mitochondria”. Biochem. Soc. Trans. 14: 698-698.
- ↑ Healy, M.J., Kerner, J. and Bieber, L.L. (1988). „Enzymes of carnitine acylation. Is overt carnitine palmitoyltransferase of liver peroxisomal carnitine octanoyltransferase?”. Biochem. J. 249: 231-237. PMID 3342008.
- ↑ Miyazawa, S., Ozasa, H., Osumi, T. and Hashimoto, T. (1983). „Purification and properties of carnitine octanoyltransferase and carnitine palmitoyltransferase from rat liver”. J. Biochem. (Tokyo) 94: 529-542. PMID 6630173.
Literatura
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.