Linoleat 11-lipoksigenaza
| Linoleat 11-lipoksigenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.13.11.45 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Linoleat 11-lipoksigenaza (EC 1.13.11.45, linoleatna dioksigenaza, manganska lipoksigenaza) je enzim sa sistematskim imenom linoleat:kiseonik 11S-oksidoreduktaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- linoleat + O2 (9Z,12Z)-(11S)-11-hidroperoksioktadeka-9,12-dienoat
Produkt (9Z,12Z)-(11S)-11-hidroperoksioktadeka-9,12-dienoat, se konvertuje u (9Z,11E)-(13R)-13-hidroperoksioktadeka-9,11-dienoat.
Reference
- ↑ Hamberg, M., Su, C. and Oliw, E.H. (1998). „Manganese lipoxygenase: Discovery of bis-allylic hydroperoxide as product and intermediate in a lipoxygenase reaction”. J. Biol. Chem. 273: 13080-13088. PMID 9582346.
- ↑ Oliw, E.H., Su, C., Skogstrom, T. and Benthin, G. (1998). „Analysis of novel hydroperoxides and other metabolites of oleic, linoleic and linolenic acids by liquid chromatography-mass spectrometry with ion trap MSn”. Lipids 33: 843-852. PMID 9778131.
- ↑ Su, C. and Oliw, E.H. (1998). „Manganese lipoxygenase: Purification and characterization”. J. Biol. Chem. 273: 13072-13079. PMID 9582345.
Literatura
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.