Rolofilin

Rolofilin
(IUPAC) ime
8-(Heksahidro-2,5-metanopentalen-3a(1H)-il)-3,7-dihidro-1,3-dipropil-1H-purin-2,6-dion
Klinički podaci
Identifikatori
CAS broj 136199-02-5
ATC kod C03BD
PubChem[1][2] 64627
ChemSpider[3] 58188
UNII 7805S5HIHX DaY
Hemijski podaci
Formula C20H28N4O2 
Mol. masa 356,46 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća ?
Pravni status ℞-only (SAD)

Rolofilin (KW-3902) je eksperimentalni diuretik koji deluje kao selektivni antagonist adenozinskog A1 receptora.[4][5]

Reference

  1. ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.  edit
  4. ↑ Givertz MM, Massie BM, Fields TK, Pearson LL, Dittrich HC (October 2007). „The effects of KW-3902, an adenosine A1-receptor antagonist,on diuresis and renal function in patients with acute decompensated heart failure and renal impairment or diuretic resistance”. J. Am. Coll. Cardiol. 50 (16): 1551–60. DOI:10.1016/j.jacc.2007.07.019. PMID 17936154. 
  5. ↑ Cotter G, Dittrich HC, Weatherley BD, Bloomfield DM, O'Connor CM, Metra M, Massie BM (October 2008). „The PROTECT pilot study: a randomized, placebo-controlled, dose-finding study of the adenosine A1 receptor antagonist rolofylline in patients with acute heart failure and renal impairment”. Journal of Cardiac Failure 14 (8): 631–40. DOI:10.1016/j.cardfail.2008.08.010. PMID 18926433. 

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