TYRO3

TYRO3 proteinska tirozinska kinaza
	; PDB prikaz baziran na 1rhf.
Dostupne strukture
	1RHF
Identifikatori
Simboli	TYRO3; BYK; Dtk; RSE; Sky; Tif
Vanjski ID	OMIM: 600341 MGI: 104294 HomoloGene: 4585 GeneCards: TYRO3 Gene
EC broj	2.7.10.1
Ontologija gena
Molekulska funkcija	• aktivnost proteinske tirozinske kinaze; • aktivnost transmembranske receptorske proteinske tirozinske kinaze; • proteinsko vezivanje; • ATP vezivanje;
Ćelijska komponenta	• nukleus; • omotač jedra; • membrana endoplazmatskog retikuluma; • integralna komponenta ćelijske membrane;
Biološki proces	• diferencijacija prirodnih ćelija ubica; • ćelijska adhezija; • prenos signala;
Pregled RNK izražavanja
	podaci
Ortolozi

edit

Tirozinski proteinsko kinazni receptor TYRO3 je enzim koji je kod ljudi kodiran TYRO3 genom.^[1]^[2]

Interakcije

TYRO3 formira interakcije sa PIK3R1^[3] i GAS6.^[4]^[5]

Reference

↑ Richard I, Broux O, Chiannilkulchai N, Fougerousse F, Allamand V, Bourg N, Brenguier L, Devaud C i dr.. (March 1995). „Regional localization of human chromosome 15 loci”. Genomics 23 (3): 619–27. DOI:10.1006/geno.1994.1550. PMID 7851890.
↑ „Entrez Gene: TYRO3 TYRO3 protein tyrosine kinase”.
↑ Lan, Z; Wu H; Li W; Wu S; Lu L; Xu M; Dai W (January 2000). „Transforming activity of receptor tyrosine kinase tyro3 is mediated, at least in part, by the PI3 kinase-signaling pathway”. Blood (UNITED STATES) 95 (2): 633–8. ISSN 0006-4971. PMID 10627473.
↑ Mark, M R; Chen J; Hammonds R G; Sadick M; Godowsk P J (April 1996). „Characterization of Gas6, a member of the superfamily of G domain-containing proteins, as a ligand for Rse and Axl”. J. Biol. Chem. (UNITED STATES) 271 (16): 9785–9. DOI:10.1074/jbc.271.16.9785. ISSN 0021-9258. PMID 8621659.
↑ Nagata, K; Ohashi K; Nakano T; Arita H; Zong C; Hanafusa H; Mizuno K (November 1996). „Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases”. J. Biol. Chem. (UNITED STATES) 271 (47): 30022–7. DOI:10.1074/jbc.271.47.30022. ISSN 0021-9258. PMID 8939948.

Literatura

Mark MR, Scadden DT, Wang Z i dr.. (1994). „rse, a novel receptor-type tyrosine kinase with homology to Axl/Ufo, is expressed at high levels in the brain”. J. Biol. Chem. 269 (14): 10720–8. PMID 7511603.
Toshima J, Ohashi K, Iwashita S, Mizuno K (1995). „Autophosphorylation activity and association with Src family kinase of Sky receptor tyrosine kinase”. Biochem. Biophys. Res. Commun. 209 (2): 656–63. DOI:10.1006/bbrc.1995.1549. PMID 7537495.
Crosier KE, Hall LR, Lewis PM i dr.. (1995). „Isolation and characterization of the human DTK receptor tyrosine kinase”. Growth Factors 11 (2): 137–44. DOI:10.3109/08977199409001055. PMID 7857658.
Ohashi K, Mizuno K, Kuma K i dr.. (1994). „Cloning of the cDNA for a novel receptor tyrosine kinase, Sky, predominantly expressed in brain”. Oncogene 9 (3): 699–705. PMID 8108112.
Dai W, Pan H, Hassanain H i dr.. (1994). „Molecular cloning of a novel receptor tyrosine kinase, tif, highly expressed in human ovary and testis”. Oncogene 9 (3): 975–9. PMID 8108143.
Polvi A, Armstrong E, Lai C i dr.. (1994). „The human TYRO3 gene and pseudogene are located in chromosome 15q14-q25”. Gene 134 (2): 289–93. DOI:10.1016/0378-1119(93)90109-G. PMID 8262388.
Mark MR, Chen J, Hammonds RG i dr.. (1996). „Characterization of Gas6, a member of the superfamily of G domain-containing proteins, as a ligand for Rse and Axl”. J. Biol. Chem. 271 (16): 9785–9. DOI:10.1074/jbc.271.16.9785. PMID 8621659.
Crosier PS, Freeman SA, Orlic D i dr.. (1996). „The Dtk receptor tyrosine kinase, which binds protein S, is expressed during hematopoiesis”. Exp. Hematol. 24 (2): 318–23. PMID 8641360.
Nagata K, Ohashi K, Nakano T i dr.. (1997). „Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases”. J. Biol. Chem. 271 (47): 30022–7. DOI:10.1074/jbc.271.47.30022. PMID 8939948.
Kajii Y, Ninomiya D, Kato M i dr.. (1997). „A tyrosine kinase-like molecule is localized in the nuclear membrane of neurons: hippocampal behavior under stress”. Biol. Cell 88 (1–2): 45–54. DOI:10.1016/S0248-4900(97)86830-X. PMID 9175267.
Lan Z, Wu H, Li W i dr.. (2000). „Transforming activity of receptor tyrosine kinase tyro3 is mediated, at least in part, by the PI3 kinase-signaling pathway”. Blood 95 (2): 633–8. PMID 10627473.
Strausberg RL, Feingold EA, Grouse LH i dr.. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Yin JL, Hambly BD, Bao SS i dr.. (2004). „Expression of growth arrest-specific gene 6 and its receptors in dysfunctional human renal allografts”. Transpl. Int. 16 (9): 681–8. DOI:10.1007/s00147-003-0593-3. PMID 12768229.
Heiring C, Dahlbäck B, Muller YA (2004). „Ligand recognition and homophilic interactions in Tyro3: structural insights into the Axl/Tyro3 receptor tyrosine kinase family”. J. Biol. Chem. 279 (8): 6952–8. DOI:10.1074/jbc.M311750200. PMID 14623883.
Ota T, Suzuki Y, Nishikawa T i dr.. (2004). „Complete sequencing and characterization of 21,243 full-length human cDNAs”. Nat. Genet. 36 (1): 40–5. DOI:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA i dr.. (2004). „The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Gould WR, Baxi SM, Schroeder R i dr.. (2005). „Gas6 receptors Axl, Sky and Mer enhance platelet activation and regulate thrombotic responses”. J. Thromb. Haemost. 3 (4): 733–41. DOI:10.1111/j.1538-7836.2005.01186.x. PMID 15733062.
Hafizi S, Gustafsson A, Stenhoff J, Dahlbäck B (2005). „The Ran binding protein RanBPM interacts with Axl and Sky receptor tyrosine kinases”. Int. J. Biochem. Cell Biol. 37 (11): 2344–56. DOI:10.1016/j.biocel.2005.05.006. PMID 15964779.
Shimojima M, Takada A, Ebihara H i dr.. (2006). „Tyro3 Family-Mediated Cell Entry of Ebola and Marburg Viruses”. J. Virol. 80 (20): 10109–16. DOI:10.1128/JVI.01157-06. PMC 1617303. PMID 17005688.

[pmid7851890-1] Richard I, Broux O, Chiannilkulchai N, Fougerousse F, Allamand V, Bourg N, Brenguier L, Devaud C i dr.. (March 1995). „Regional localization of human chromosome 15 loci”. Genomics 23 (3): 619–27. DOI:10.1006/geno.1994.1550. PMID 7851890.

[entrez-2] „Entrez Gene: TYRO3 TYRO3 protein tyrosine kinase”.

[pmid10627473-3] Lan, Z; Wu H; Li W; Wu S; Lu L; Xu M; Dai W (January 2000). „Transforming activity of receptor tyrosine kinase tyro3 is mediated, at least in part, by the PI3 kinase-signaling pathway”. Blood (UNITED STATES) 95 (2): 633–8. ISSN 0006-4971. PMID 10627473.

[pmid8621659-4] Mark, M R; Chen J; Hammonds R G; Sadick M; Godowsk P J (April 1996). „Characterization of Gas6, a member of the superfamily of G domain-containing proteins, as a ligand for Rse and Axl”. J. Biol. Chem. (UNITED STATES) 271 (16): 9785–9. DOI:10.1074/jbc.271.16.9785. ISSN 0021-9258. PMID 8621659.

[pmid8939948-5] Nagata, K; Ohashi K; Nakano T; Arita H; Zong C; Hanafusa H; Mizuno K (November 1996). „Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases”. J. Biol. Chem. (UNITED STATES) 271 (47): 30022–7. DOI:10.1074/jbc.271.47.30022. ISSN 0021-9258. PMID 8939948.

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