Glutaril-7-aminocefalosporansko-kiselinska acilaza
Glutaril-7-aminocefalosporansko-kiselinska acilaza | |||||||||
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Identifikatori | |||||||||
EC broj | 3.5.1.93 | ||||||||
CAS broj | 56645-46-6 | ||||||||
Baze podataka | |||||||||
IntEnz | IntEnz pregled | ||||||||
BRENDA | BRENDA pristup | ||||||||
ExPASy | NiceZyme pregled | ||||||||
KEGG | KEGG pristup | ||||||||
MetaCyc | metabolički put | ||||||||
PRIAM | profil | ||||||||
Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Glutaril-7-aminocefalosporansko-kiselinska acilaza (EC 3.5.1.93, 7beta-(4-karboksibutanamido)cefalosporansko kiselinska acilaza, cefalosporin C acilaza, glutaril-7-ACA acilaza, CA, GCA, GA, cefalosporinska acilaza, glutaril-7-aminocefalosporanska kiselinskaa acilaza, GL-7-ACA acilaza) je enzim sa sistematskim imenom (7R)-7-(4-karboksibutanamido)cefalosporanat amidohidrolaza.[1][2][3][4][5][6][7] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (7R)-7-(4-karboksibutanamido)cefalosporanat + H2O (7R)-7-aminocefalosporanat + glutarat
Ovaj enzim formira 7-aminocefalosporansku kiselinu.
Reference
- ^ Ishii, Y., Saito, Y., Fujimura, T., Sasaki, H., Noguchi, Y., Yamada, H., Niwa, M. and Shimomura, K. (1995). „High-level production, chemical modification and site-directed mutagenesis of a cephalosporin C acylase from Pseudomonas strain N176”. Eur. J. Biochem. 230: 773—778. PMID 7607251.
- ^ Kinoshita, T., Tada, T., Saito, Y., Ishii, Y., Sato, A. and Murata, M. (2000). „Crystallization and preliminary X-ray analysis of cephalosporin C acylase from Pseudomonas sp. strain N176”. Acta Crystallogr. D Biol. Crystallogr. 56: 458—459. PMID 10739919.
- ^ Monti, D., Carrea, G., Riva, S., Baldaro, E. and Frare, G. (2000). „Characterization of an industrial biocatalyst: immobilized glutaryl-7-ACA acylase”. Biotechnol. Bioeng. 70: 239—244. PMID 10972935.
- ^ Kwon, T.H., Rhee, S., Lee, Y.S., Park, S.S. and Kim, K.H. (2000). „Crystallization and preliminary X-Ray diffraction analysis of glutaryl-7-aminocephalosporanic acid acylase from Pseudomonas sp. GK16”. J. Struct. Biol. 131: 79—81. PMID 10945972.
- ^ Kim, Y., Yoon, K.-H., Khang, Y., Turley, S. and Hol, W.G.J. (2000). „The 2.0 Å crystal structure of cephalosporin acylase”. Structure. 8: 1059—1068. PMID 11080627.
- ^ Huang, X., Zeng, R., Ding, X., Mao, X., Ding, Y., Rao, Z., Xie, Y., Jiang, W. and Zhao, G. (2002). „Affinity alkylation of the Trp-B4 residue of the β-subunit of the glutaryl 7-aminocephalosporanic acid acylase of Pseudomonas sp. 130”. J. Biol. Chem. 277: 10256—10264. PMID 11782466.
- ^ Kim, J.K., Yang, I.S., Rhee, S., Dauter, Z., Lee, Y.S., Park, S.S. and Kim, K.H. (2003). „Crystal structures of glutaryl 7-aminocephalosporanic acid acylase: insight into autoproteolytic activation”. Biochemistry. 42: 4084—4093. PMID 12680762.
Literatura
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze
- Glutaryl-7-aminocephalosporanic-acid+acylase на US National Library of Medicine Medical Subject Headings (MeSH)