肿瘤微环境

肿瘤微环境(英語:Tumor microenvironment)是指肿瘤细胞存在的周围微环境,包括周围的血管、免疫细胞、成纤维细胞、骨髓源性炎性细胞、各种信号分子和细胞外基质(ECM)。[1][2][3]

肿瘤和周围环境密切相关,不断进行交互作用,肿瘤可以通过释放细胞信号分子影响其微环境环境,促进肿瘤的血管生成和诱导免疫耐受,而微环境中的免疫细胞可影响癌细胞增长和发育。[4] 腫瘤微環境中常見的免疫細胞特性包含以下三者[5]:(1)具細胞毒殺功能的自然殺手細胞細胞毒性T細胞數量減少;(2)具免疫抑制功能的骨髓來源的抑制性細胞(Myeloid-derived suppressor cell, MDSC)及調節T細胞數量增加[6];(3)巨噬細胞嗜中性球分別由具促發炎能力的M1及N1表型,轉變為具抑制免疫反應而能促進腫瘤生長的M2及N2表型[7]

肿瘤微环境有助于肿瘤异质性英语Tumour heterogeneity的形成。

参考文献

  1. ^ NCI Dictionary of Cancer Terms. National Cancer Institute. [2018-05-25]. (原始内容存档于2015-05-09). 
  2. ^ Joyce, Johanna A.; Fearon, Douglas T. T cell exclusion, immune privilege, and the tumor microenvironment. Science Magazine: 74–80. 3 April 2015 [2015-06-25]. doi:10.1126/science.aaa6204. (原始内容存档于2015-09-24).  |volume=被忽略 (帮助); |issue=被忽略 (帮助)
  3. ^ Spill, F.; Reynolds, D.S.; Kamm, R.D.; Zaman, M.H. Impact of the physical microenvironment on tumor progression and metastasis. Current Opinion in Biotechnology: 41–48. [2018-05-25]. doi:10.1016/j.copbio.2016.02.007. (原始内容存档于2020-05-30). 
  4. ^ Korneev, KV; Atretkhany, KN; Drutskaya, MS; Grivennikov, SI; Kuprash, DV; Nedospasov, SA. TLR-signaling and proinflammatory cytokines as drivers of tumorigenesis.. Cytokine. January 2017, 89: 127–135. PMID 26854213. doi:10.1016/j.cyto.2016.01.021. 
  5. ^ Calvani, M; Bruno, G; Dal Monte, M. β3‐Adrenoceptor as a potential immuno‐suppressor agent in melanoma.. Br J Pharmacol. March 2019, 176: 2509–2524. doi:10.1111/bph.14660. 
  6. ^ Vinay, D. S.; Ryan, E. P.; Pawelec, G; Talib, W. H.; Stagg, J.; Elkord, E.; Kwon, B. S. Immune evasion in cancer: Mechanistic basis and therapeutic strategies.. Seminars in Cancer Biology. December 2015,. 35(Suppl): S185–S198 [2020-12-21]. doi:10.1016/j.semcancer.2015.03.004. (原始内容存档于2020-11-12). 
  7. ^ Mareike; Möller, Sonja; Laskay, Tamás. An Attempt to Polarize Human Neutrophils Toward N1 and N2 Phenotypes in vitro.. Frontiers in Immunology. April 2020 [2020-12-21]. doi:10.3389/fimmu.2020.00532. (原始内容存档于2020-09-03).