PARK7

PARK7
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1J42, 1P5F, 1PDV, 1PDW, 1PE0, 1Q2U, 1SOA, 1UCF, 2OR3, 2R1T, 2R1U, 2R1V, 2RK3, 2RK4, 2RK6, 3B36, 3B38, 3B3A, 3BWE, 3CY6, 3CYF, 3CZ9, 3CZA, 3EZG, 3F71, 3SF8, 4BTE, 4MNT, 4MTC, 4N0M, 4N12, 4OGF, 4OQ4, 4P2G, 4P34, 4P35, 4P36, 4ZGG, 4RKW, 4RKY, 4S0Z
Dynodwyr
Cyfenwau	PARK7, DJ-1, DJ1, HEL-S-67p, Parkinsonism associated deglycase, GATD2
Dynodwyr allanol	OMIM: 602533 HomoloGene: 38295 GeneCards: PARK7
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • signaling receptor binding • GO:0019974 cytokine binding • cupric ion binding • transcription factor binding • L-dopa decarboxylase activator activity • GO:0070122 peptidase activity • kinase binding • tyrosine 3-monooxygenase activator activity • enzyme binding • mRNA binding • protein homodimerization activity • scaffold protein binding • small protein activating enzyme binding • single-stranded DNA binding • ubiquitin-like protein conjugating enzyme binding • GO:0001948, GO:0016582 protein binding • peroxiredoxin activity • double-stranded DNA binding • copper ion binding • mercury ion binding • GO:0001105 transcription coactivator activity • oxidoreductase activity, acting on peroxide as acceptor • androgen receptor binding • superoxide dismutase copper chaperone activity • RNA binding • identical protein binding • ubiquitin-specific protease binding • hydrolase activity • cuprous ion binding • cadherin binding • protein deglycase activity • GO:0032403 protein-containing complex binding Cydrannau o'r gell • cytoplasm • cytosol • bilen • mitochondrial intermembrane space • mitocondria • neuron projection • cnewyllyn cell • mitochondrial respiratory chain complex I • Reticwlwm endoplasmig • membrane raft • chromatin • extracellular exosome • Cellbilen • mitochondrial matrix • cell body • PML body • presynapse • perinuclear region of cytoplasm • axon • nucleoplasm Prosesau biolegol • GO:1904089 negative regulation of neuron apoptotic process • positive regulation of transcription regulatory region DNA binding • negative regulation of protein sumoylation • negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway • negative regulation of protein binding • synaptic transmission, dopaminergic • positive regulation of interleukin-8 production • negative regulation of proteasomal ubiquitin-dependent protein catabolic process • Ras protein signal transduction • cellular response to glyoxal • negative regulation of protein acetylation • positive regulation of reactive oxygen species biosynthetic process • positive regulation of oxidative phosphorylation uncoupler activity • positive regulation of protein kinase B signaling • GO:1903363 negative regulation of protein catabolic process • adult locomotory behavior • regulation of neuron apoptotic process • negative regulation of extrinsic apoptotic signaling pathway • negative regulation of cell death • glycolate biosynthetic process • positive regulation of protein homodimerization activity • negative regulation of gene expression • single fertilization • positive regulation of peptidyl-serine phosphorylation • positive regulation of mitochondrial electron transport, NADH to ubiquinone • negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway • negative regulation of oxidative stress-induced cell death • inflammatory response • negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway • regulation of supramolecular fiber organization • negative regulation of neuron death • GO:0033128 negative regulation of protein phosphorylation • negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway • negative regulation of protein kinase activity • negative regulation of oxidative stress-induced neuron death • membrane depolarization • protein stabilization • mitochondrion organization • positive regulation of DNA-binding transcription factor activity • negative regulation of death-inducing signaling complex assembly • negative regulation of apoptotic process • proteolysis • negative regulation of protein K48-linked deubiquitination • dopamine uptake involved in synaptic transmission • positive regulation of tyrosine 3-monooxygenase activity • positive regulation of L-dopa decarboxylase activity • negative regulation of hydrogen peroxide-induced neuron death • regulation of inflammatory response • regulation of androgen receptor signaling pathway • negative regulation of hydrogen peroxide-induced cell death • positive regulation of autophagy of mitochondrion • response to hydrogen peroxide • detoxification of copper ion • positive regulation of superoxide dismutase activity • positive regulation of dopamine biosynthetic process • positive regulation of protein localization to nucleus • positive regulation of L-dopa biosynthetic process • activation of protein kinase B activity • membrane hyperpolarization • detoxification of mercury ion • negative regulation of TRAIL-activated apoptotic signaling pathway • cellular oxidant detoxification • negative regulation of ubiquitin-specific protease activity • autophagy • GO:0072353 cellular response to reactive oxygen species • regulation of mitochondrial membrane potential • negative regulation of protein ubiquitination • hydrogen peroxide metabolic process • GO:1901313 positive regulation of gene expression • negative regulation of protein export from nucleus • negative regulation of ubiquitin-protein transferase activity • positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway • cellular response to oxidative stress • positive regulation of androgen receptor activity • positive regulation of pyrroline-5-carboxylate reductase activity • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • cellular response to hydrogen peroxide • methylglyoxal metabolic process • lactate biosynthetic process • peptidyl-cysteine deglycation • peptidyl-arginine deglycation • peptidyl-lysine deglycation • protein deglycation, glyoxal removal • protein deglycation, methylglyoxal removal • glutathione deglycation • glyoxal metabolic process • negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway • positive regulation of acute inflammatory response to antigenic stimulus • protein deglycosylation • positive regulation of NAD(P)H oxidase activity • GO:0100026 DNA repair • cellular response to DNA damage stimulus • insulin secretion • glucose homeostasis • guanine deglycation • guanine deglycation, methylglyoxal removal • guanine deglycation, glyoxal removal • negative regulation of reactive oxygen species biosynthetic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	11315	n/a
Ensembl	ENSG00000116288	n/a
UniProt	Q99497	n/a
RefSeq (mRNA)	NM_001123377 NM_007262	n/a
RefSeq (protein)	NP_001116849 NP_009193	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PARK7 yw PARK7 a elwir hefyd yn Parkinsonism associated deglycase (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 1, band 1p36.23.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PARK7.

• "DJ-1, a Parkinson's disease related protein, aggregates under denaturing conditions and co-aggregates with α-synuclein through hydrophobic interaction. ". Biochim Biophys Acta. 2017. PMID 28330770.
• "Parkinsonism-associated protein DJ-1 is a bona fide deglycase. ". Biochem Biophys Res Commun. 2017. PMID 28013050.
• "DJ-1 as a potential biomarker for the early diagnosis in lung cancer patients. ". Tumour Biol. 2017. PMID 28653888.
• "DJ-1 is a reliable serum biomarker for discriminating high-risk endometrial cancer. ". Tumour Biol. 2017. PMID 28618925.
• "Identification of DJ-1 as a contributor to multidrug resistance in human small-cell lung cancer using proteomic analysis.". Int J Exp Pathol. 2017. PMID 28580701.