Aquaporin-7

AQP7
Identifiers
Aliases	AQP7, AQP7L, AQP9, AQPap, GLYCQTL, aquaporin 7
External IDs	OMIM: 602974 MGI: 1314647 HomoloGene: 48000 GeneCards: AQP7
Gene location (Human)
Chr.	Chromosome 9 (human)
End	33,402,682 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	41,048,139 bp
RNA expression pattern
	Top expressed in
	subcutaneous adipose tissue; ; left ventricle; ; sural nerve; ; gastric mucosa; ; duodenum; ; quadriceps femoris muscle; ; right lobe of liver; ; kidney; ; gastrocnemius muscle; ; skeletal muscle tissue;
	Top expressed in
	spermatid; ; seminiferous tubule; ; brown adipose tissue; ; aortic valve; ; white adipose tissue; ; proximal tubule; ; ascending aorta; ; sternocleidomastoid muscle; ; spermatocyte; ; digastric muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	glycerol channel activity; water channel activity; channel activity; urea transmembrane transporter activity;
Cellular component	cytoplasm; integral component of membrane; plasma membrane; integral component of plasma membrane; membrane; cell-cell junction; lipid droplet; cell cortex; cytoplasmic vesicle membrane; cytoplasmic vesicle;
Biological process	water transport; excretion; glycerol transport; generation of precursor metabolites and energy; transmembrane transport; urea transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	364
	11832
	ENSG00000165269
	ENSMUSG00000028427
	O14520
	O54794
NM_001170; NM_001318156; NM_001318157; NM_001318158; NM_001376191;
	NM_001376192; NM_001376193
	NM_007473
NP_001161; NP_001305085; NP_001305086; NP_001305087; NP_001363120;
	NP_001363121; NP_001363122
NP_031499; NP_001365567; NP_001365568; NP_001365569; NP_001365570;
	NP_001365571
	Wikidata
View/Edit Human	View/Edit Mouse

Aquaporin-7 (AQP-7) is a protein that in humans is encoded by the AQP7 gene.^[5]^[6]

Aquaporins/major intrinsic proteins (MIP) are a family of water-selective membrane channels. Aquaporin-7 has greater sequence similarity with AQP3 and AQP9 and they may be a subfamily. Aquaporin-7 and AQP3 are at the same chromosomal location suggesting that 9p13 may be a site of an aquaporin cluster. Aquaporin-7 facilitates water, glycerol and urea transport. It may play an important role in thermoregulation in the form of perspiration, and sperm function.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000165269 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028427 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ishibashi K, Kuwahara M, Gu Y, Kageyama Y, Tohsaka A, Suzuki F, Marumo F, Sasaki S (Sep 1997). "Cloning and functional expression of a new water channel abundantly expressed in the testis permeable to water, glycerol, and urea". J Biol Chem. 272 (33): 20782–6. doi:10.1074/jbc.272.33.20782. PMID 9252401.
^ ^a ^b "Entrez Gene: AQP7 aquaporin 7".

External links

AQP7+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Human AQP7 genome location and AQP7 gene details page in the UCSC Genome Browser.
Human AQP9 genome location and AQP9 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000165269 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028427 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9252401-5] Ishibashi K, Kuwahara M, Gu Y, Kageyama Y, Tohsaka A, Suzuki F, Marumo F, Sasaki S (Sep 1997). "Cloning and functional expression of a new water channel abundantly expressed in the testis permeable to water, glycerol, and urea". J Biol Chem. 272 (33): 20782–6. doi:10.1074/jbc.272.33.20782. PMID 9252401.

[entrez-6] "Entrez Gene: AQP7 aquaporin 7".

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[6]

Aquaporin-7

References

Further reading

External links