KRT71

KRT71
Identifiers
Aliases	KRT71, HYPT13, K6IRS1, KRT6IRS, KRT6IRS1, keratin 71
External IDs	OMIM: 608245; MGI: 1861586; HomoloGene: 88864; GeneCards: KRT71; OMA:KRT71 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	52,553,145 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	101,651,544 bp
RNA expression pattern
	Top expressed in
	skin of arm; ; skin of hip; ; nipple; ; skin of leg; ; skin of abdomen; ; right lung; ; spinal cord; ; C1 segment; ; human musculoskeletal system; ; muscular system;
	Top expressed in
	lip; ; hair follicle; ; skin of back; ; skin of abdomen; ; skin of external ear; ; embryo; ; secondary oocyte; ; zygote; ; sexually immature organism; ; primary oocyte;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; structural molecule activity;
Cellular component	cytoplasm; keratin filament; extracellular exosome; cytoskeleton; intermediate filament; cytosol;
Biological process	intermediate filament organization; hair follicle morphogenesis; keratinization; cornification;
	Sources:Amigo / QuickGO
Orthologs
	112802
	56735
	ENSG00000139648
	ENSMUSG00000051879
	Q3SY84
	Q9R0H5
	NM_033448
	NM_019956
	NP_258259
	NP_064340
	Wikidata
View/Edit Human	View/Edit Mouse

KRT71 is a keratin gene. Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins.^[5]^[6] This gene encodes a protein that is expressed in the inner root sheath of hair follicles.^[6] The type II keratins are clustered in a region of chromosome 12q13.^[6]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000139648 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000051879 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ho M, Thompson B, Fisk JN, Nebert DW, Bruford EA, Vasiliou V, Bunick CG (January 2022). "Update of the keratin gene family: evolution, tissue-specific expression patterns, and relevance to clinical disorders". Human Genomics. 16 (1): 1. doi:10.1186/s40246-021-00374-9. PMC 8733776. PMID 34991727.
^ ^a ^b ^c Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, et al. (July 2006). "New consensus nomenclature for mammalian keratins". The Journal of Cell Biology. 174 (2): 169–174. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889.
^ "KRT71 Gene symbol report". HUGO Gene Nomenclature Committee. Retrieved 2023-05-01.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000139648 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000051879 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Ho M, Thompson B, Fisk JN, Nebert DW, Bruford EA, Vasiliou V, Bunick CG (January 2022). "Update of the keratin gene family: evolution, tissue-specific expression patterns, and relevance to clinical disorders". Human Genomics. 16 (1): 1. doi:10.1186/s40246-021-00374-9. PMC 8733776. PMID 34991727.

[Schweizer_2006-6] Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, et al. (July 2006). "New consensus nomenclature for mammalian keratins". The Journal of Cell Biology. 174 (2): 169–174. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889.

[7] "KRT71 Gene symbol report". HUGO Gene Nomenclature Committee. Retrieved 2023-05-01.

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