RBPJ
Recombination signal binding protein for immunoglobulin kappa J region is a protein that in humans is encoded by the RBPJ gene.[5][6][7]
RBPJ[8] also known as CBF1, is the human homolog for the Drosophila gene Suppressor of Hairless. Its promoter region is classically used to demonstrate Notch1 signaling.[9]
Interactions
RBPJ has been shown to interact with:
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000168214 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039191 - Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Amakawa R, Jing W, Ozawa K, Matsunami N, Hamaguchi Y, Matsuda F, et al. (August 1993). "Human Jk recombination signal binding protein gene (IGKJRB): comparison with its mouse homologue". Genomics. 17 (2): 306–315. doi:10.1006/geno.1993.1326. PMID 8406481.
- ^ Tang X, Saito-Ohara F, Song J, Koga C, Ugai H, Murakami H, et al. (June 1997). "Assignment of the human gene for KBF2/RBP-Jk to chromosome 9p12-13 and 9q13 by fluorescence in situ hybridization". The Japanese Journal of Human Genetics. 42 (2): 337–341. doi:10.1007/BF02766956. PMID 9290259.
- ^ "NCBI Gene: RBPJ recombination signal binding protein for immunoglobulin kappa J region".
- ^ "HGNC: RBPJ Symbol Report".
- ^ Hsieh JJ, Henkel T, Salmon P, Robey E, Peterson MG, Hayward SD (March 1996). "Truncated mammalian Notch1 activates CBF1/RBPJk-repressed genes by a mechanism resembling that of Epstein-Barr virus EBNA2". Molecular and Cellular Biology. 16 (3): 952–959. doi:10.1128/mcb.16.3.952. PMC 231077. PMID 8622698.
- ^ Nam Y, Weng AP, Aster JC, Blacklow SC (June 2003). "Structural requirements for assembly of the CSL.intracellular Notch1.Mastermind-like 1 transcriptional activation complex". The Journal of Biological Chemistry. 278 (23): 21232–21239. doi:10.1074/jbc.M301567200. PMID 12644465.
- ^ Aster JC, Robertson ES, Hasserjian RP, Turner JR, Kieff E, Sklar J (April 1997). "Oncogenic forms of NOTCH1 lacking either the primary binding site for RBP-Jkappa or nuclear localization sequences retain the ability to associate with RBP-Jkappa and activate transcription". The Journal of Biological Chemistry. 272 (17): 11336–11343. doi:10.1074/jbc.272.17.11336. PMID 9111040.
- ^ Beatus P, Lundkvist J, Oberg C, Pedersen K, Lendahl U (June 2001). "The origin of the ankyrin repeat region in Notch intracellular domains is critical for regulation of HES promoter activity". Mechanisms of Development. 104 (1–2): 3–20. doi:10.1016/s0925-4773(01)00373-2. PMID 11404076. S2CID 9526831.
- ^ Zhou S, Hayward SD (September 2001). "Nuclear localization of CBF1 is regulated by interactions with the SMRT corepressor complex". Molecular and Cellular Biology. 21 (18): 6222–6232. doi:10.1128/mcb.21.18.6222-6232.2001. PMC 87339. PMID 11509665.
- ^ Kurooka H, Honjo T (June 2000). "Functional interaction between the mouse notch1 intracellular region and histone acetyltransferases PCAF and GCN5". The Journal of Biological Chemistry. 275 (22): 17211–17220. doi:10.1074/jbc.M000909200. PMID 10747963.
- ^ a b Zhou S, Fujimuro M, Hsieh JJ, Chen L, Hayward SD (February 2000). "A role for SKIP in EBNA2 activation of CBF1-repressed promoters". Journal of Virology. 74 (4): 1939–1947. doi:10.1128/jvi.74.4.1939-1947.2000. PMC 111672. PMID 10644367.
- ^ Hsieh JJ, Zhou S, Chen L, Young DB, Hayward SD (January 1999). "CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex". Proceedings of the National Academy of Sciences of the United States of America. 96 (1): 23–28. Bibcode:1999PNAS...96...23H. doi:10.1073/pnas.96.1.23. PMC 15086. PMID 9874765.
- ^ Zhou S, Fujimuro M, Hsieh JJ, Chen L, Miyamoto A, Weinmaster G, Hayward SD (April 2000). "SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function". Molecular and Cellular Biology. 20 (7): 2400–2410. doi:10.1128/mcb.20.7.2400-2410.2000. PMC 85419. PMID 10713164.
- ^ Overman J, Fontaine F, Wylie-Sears J, Moustaqil M, Huang L, Meurer M, et al. (July 2019). van Lohuizen M, Koh GY, Ostergaard P (eds.). "R-propranolol is a small molecule inhibitor of the SOX18 transcription factor in a rare vascular syndrome and hemangioma". eLife. 8: e43026. doi:10.7554/eLife.43026. PMC 6667216. PMID 31358114.
- ^ Díaz-Trelles R, Scimia MC, Bushway P, Tran D, Monosov A, Monosov E, et al. (June 2016). "Notch-independent RBPJ controls angiogenesis in the adult heart". Nature Communications. 7 (1): 12088. Bibcode:2016NatCo...712088D. doi:10.1038/ncomms12088. PMC 4931341. PMID 27357444.
Further reading
- Oka C, Kawaichi M (1995). "V(D)J recombination of immunoglobulin genes". Advances in Biophysics. 31: 163–180. doi:10.1016/0065-227X(95)99390-B. PMID 7625272.
- Matsunami N, Hamaguchi Y, Yamamoto Y, Kuze K, Kangawa K, Matsuo H, et al. (1990). "A protein binding to the J kappa recombination sequence of immunoglobulin genes contains a sequence related to the integrase motif". Nature. 342 (6252): 934–937. doi:10.1038/342934a0. PMID 2556644. S2CID 4370462.
- Tong X, Drapkin R, Yalamanchili R, Mosialos G, Kieff E (September 1995). "The Epstein-Barr virus nuclear protein 2 acidic domain forms a complex with a novel cellular coactivator that can interact with TFIIE". Molecular and Cellular Biology. 15 (9): 4735–4744. doi:10.1128/mcb.15.9.4735. PMC 230717. PMID 7651391.
- Zhao B, Marshall DR, Sample CE (July 1996). "A conserved domain of the Epstein-Barr virus nuclear antigens 3A and 3C binds to a discrete domain of Jkappa". Journal of Virology. 70 (7): 4228–4236. doi:10.1128/JVI.70.7.4228-4236.1996. PMC 190353. PMID 8676443.
- Tamura K, Taniguchi Y, Minoguchi S, Sakai T, Tun T, Furukawa T, Honjo T (December 1995). "Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-J kappa/Su(H)". Current Biology. 5 (12): 1416–1423. doi:10.1016/S0960-9822(95)00279-X. hdl:2433/202204. PMID 8749394. S2CID 18442572.
- Gress TM, Müller-Pillasch F, Geng M, Zimmerhackl F, Zehetner G, Friess H, et al. (October 1996). "A pancreatic cancer-specific expression profile". Oncogene. 13 (8): 1819–1830. PMID 8895530.
- Hsieh JJ, Nofziger DE, Weinmaster G, Hayward SD (March 1997). "Epstein-Barr virus immortalization: Notch2 interacts with CBF1 and blocks differentiation". Journal of Virology. 71 (3): 1938–1945. doi:10.1128/JVI.71.3.1938-1945.1997. PMC 191274. PMID 9032325.
- Aster JC, Robertson ES, Hasserjian RP, Turner JR, Kieff E, Sklar J (April 1997). "Oncogenic forms of NOTCH1 lacking either the primary binding site for RBP-Jkappa or nuclear localization sequences retain the ability to associate with RBP-Jkappa and activate transcription". The Journal of Biological Chemistry. 272 (17): 11336–11343. doi:10.1074/jbc.272.17.11336. PMID 9111040.
- Kao HY, Ordentlich P, Koyano-Nakagawa N, Tang Z, Downes M, Kintner CR, et al. (August 1998). "A histone deacetylase corepressor complex regulates the Notch signal transduction pathway". Genes & Development. 12 (15): 2269–2277. doi:10.1101/gad.12.15.2269. PMC 317043. PMID 9694793.
- Hsieh JJ, Zhou S, Chen L, Young DB, Hayward SD (January 1999). "CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex". Proceedings of the National Academy of Sciences of the United States of America. 96 (1): 23–28. Bibcode:1999PNAS...96...23H. doi:10.1073/pnas.96.1.23. PMC 15086. PMID 9874765.
- Scanlan MJ, Gordan JD, Williamson B, Stockert E, Bander NH, Jongeneel V, et al. (November 1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". International Journal of Cancer. 83 (4): 456–464. doi:10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5. PMID 10508479.
- Callahan J, Aster J, Sklar J, Kieff E, Robertson ES (January 2000). "Intracellular forms of human NOTCH1 interact at distinctly different levels with RBP-jkappa in human B and T cells". Leukemia. 14 (1): 84–92. doi:10.1038/sj.leu.2401630. PMID 10637481.
- Smith PR, de Jesus O, Turner D, Hollyoake M, Karstegl CE, Griffin BE, et al. (April 2000). "Structure and coding content of CST (BART) family RNAs of Epstein-Barr virus". Journal of Virology. 74 (7): 3082–3092. doi:10.1128/JVI.74.7.3082-3092.2000. PMC 111807. PMID 10708423.
- Zhou S, Fujimuro M, Hsieh JJ, Chen L, Miyamoto A, Weinmaster G, Hayward SD (April 2000). "SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function". Molecular and Cellular Biology. 20 (7): 2400–2410. doi:10.1128/MCB.20.7.2400-2410.2000. PMC 85419. PMID 10713164.
- Kurooka H, Honjo T (June 2000). "Functional interaction between the mouse notch1 intracellular region and histone acetyltransferases PCAF and GCN5". The Journal of Biological Chemistry. 275 (22): 17211–17220. doi:10.1074/jbc.M000909200. PMID 10747963.
- Beatus P, Lundkvist J, Oberg C, Pedersen K, Lendahl U (June 2001). "The origin of the ankyrin repeat region in Notch intracellular domains is critical for regulation of HES promoter activity". Mechanisms of Development. 104 (1–2): 3–20. doi:10.1016/S0925-4773(01)00373-2. PMID 11404076. S2CID 9526831.
- Zhou S, Hayward SD (September 2001). "Nuclear localization of CBF1 is regulated by interactions with the SMRT corepressor complex". Molecular and Cellular Biology. 21 (18): 6222–6232. doi:10.1128/MCB.21.18.6222-6232.2001. PMC 87339. PMID 11509665.
External links
- RBPJ+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.