SPRY4
Protein-coding gene in the species Homo sapiens
Protein sprouty homolog 4protein that in humans is encoded by the SPRY4 gene .[5] [6]
Function SPRY4 is an inhibitor of the receptor-transduced mitogen-activated protein kinase (MAPK) signaling pathway. It is positioned upstream of RAS (see HRAS; MIM 190020) activation and impairs the formation of active GTP-RAS (Leeksma et al., 2002).[6]
Interactions SPRY4 has been shown to interact with TESK1 .[7]
See also References
^ a b c GRCh38: Ensembl release 89: ENSG00000187678 - Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024427 - Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Katoh Y, Katoh M (Mar 2006). "FGF signaling inhibitor, SPRY4, is evolutionarily conserved target of WNT signaling pathway in progenitor cells" . International Journal of Molecular Medicine . 17 (3): 529–32. doi :10.3892/ijmm.17.3.529 PMID 16465403 . ^ a b "Entrez Gene: SPRY4 sprouty homolog 4 (Drosophila)" .^ Leeksma OC, Van Achterberg TA, Tsumura Y, Toshima J, Eldering E, Kroes WG, Mellink C, Spaargaren M, Mizuno K, Pannekoek H, de Vries CJ (May 2002). "Human sprouty 4, a new ras antagonist on 5q31, interacts with the dual specificity kinase TESK1" . European Journal of Biochemistry . 269 (10): 2546–56. doi :10.1046/j.1432-1033.2002.02921.x PMID 12027893 .
Further reading
Zaharieva I, Georgieva L, Nikolov I, Kirov G, Owen MJ, O'Donovan MC, Toncheva D (2008). "Association study in the 5q31-32 linkage region for schizophrenia using pooled DNA genotyping" . BMC Psychiatry . 8 : 11. doi :10.1186/1471-244X-8-11 PMC 2268687 PMID 18298822 . Cabrita MA, Jäggi F, Widjaja SP, Christofori G (Sep 2006). "A functional interaction between sprouty proteins and caveolin-1" . The Journal of Biological Chemistry . 281 (39): 29201–12. doi :10.1074/jbc.M603921200 PMID 16877379 . Wang J, Thompson B, Ren C, Ittmann M, Kwabi-Addo B (May 2006). "Sprouty4, a suppressor of tumor cell motility, is down regulated by DNA methylation in human prostate cancer" . The Prostate . 66 (6): 613–24. doi :10.1002/pros.20353 PMID 16388505 . S2CID 43803094 . Ding W, Bellusci S, Shi W, Warburton D (Jul 2004). "Genomic structure and promoter characterization of the human Sprouty4 gene, a novel regulator of lung morphogenesis". American Journal of Physiology. Lung Cellular and Molecular Physiology . 287 (1): L52-9. doi :10.1152/ajplung.00430.2003 . PMID 14977631 . Sasaki A, Taketomi T, Kato R, Saeki K, Nonami A, Sasaki M, Kuriyama M, Saito N, Shibuya M, Yoshimura A (May 2003). "Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1". Nature Cell Biology . 5 (5): 427–32. doi :10.1038/ncb978 . PMID 12717443 . S2CID 33846459 . Leeksma OC, Van Achterberg TA, Tsumura Y, Toshima J, Eldering E, Kroes WG, Mellink C, Spaargaren M, Mizuno K, Pannekoek H, de Vries CJ (May 2002). "Human sprouty 4, a new ras antagonist on 5q31, interacts with the dual specificity kinase TESK1" . European Journal of Biochemistry . 269 (10): 2546–56. doi :10.1046/j.1432-1033.2002.02921.x PMID 12027893 .
External links PDBe-KB provides an overview of all the structure information available in the PDB for Human Protein sprouty homolog 4 (SPRY4)
The article is a derivative under the Creative Commons Attribution-ShareAlike License .
A link to the original article can be found here and attribution parties here
By using this site, you agree to the Terms of Use . Gpedia ® is a registered trademark of the Cyberajah Pty Ltd
