TESK1

TESK1
Identifiers
Aliases	TESK1, testis-specific kinase 1, testis associated actin remodelling kinase 1
External IDs	OMIM: 601782 MGI: 1201675 HomoloGene: 4577 GeneCards: TESK1
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	43,448,064 bp
RNA expression pattern
	Top expressed in
	left coronary artery; ; right coronary artery; ; ascending aorta; ; anterior pituitary; ; gastrocnemius muscle; ; gastric mucosa; ; canal of the cervix; ; left lobe of thyroid gland; ; body of stomach; ; subcutaneous adipose tissue;
	Top expressed in
	seminiferous tubule; ; spermatid; ; spermatocyte; ; superior frontal gyrus; ; internal carotid artery; ; entorhinal cortex; ; external carotid artery; ; lip; ; brown adipose tissue; ; cerebellar cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein serine/threonine/tyrosine kinase activity; protein tyrosine kinase activity; protein kinase activity; protein binding; ATP binding; metal ion binding; kinase activity; protein serine/threonine kinase activity; signal transducer activity; protein C-terminus binding; protein kinase binding;
Cellular component	cytosol; cytoplasm; nucleus; cytoplasmic vesicle;
Biological process	peptidyl-tyrosine phosphorylation; spermatogenesis; phosphorylation; intracellular signal transduction; protein phosphorylation; actin cytoskeleton organization; negative regulation of protein autophosphorylation; regulation of protein localization; positive regulation of stress fiber assembly; negative regulation of protein serine/threonine kinase activity;
	Sources:Amigo / QuickGO
Orthologs
	7016
	21754
	n/a
	ENSMUSG00000028458
	Q15569
	O70146
	NM_006285; NM_001318230
	NM_011571
	NP_001305159; NP_006276
	NP_035701
	Wikidata
View/Edit Human	View/Edit Mouse

Dual specificity testis-specific protein kinase 1 is an enzyme that in humans is encoded by the TESK1 gene.^[4]^[5]

Function

This gene product is a serine/threonine protein kinase that contains an N-terminal protein kinase domain and a C-terminal proline-rich domain. Its protein kinase domain is most closely related to those of the LIM motif-containing protein kinases (LIMKs). The encoded protein can phosphorylate myelin basic protein and histone in vitro. The testicular germ cell-specific expression and developmental pattern of expression of the mouse gene suggests that this gene plays an important role at and after the meiotic phase of spermatogenesis.^[5]

Interactions

TESK1 has been shown to interact with YWHAB^[6] and SPRY4.^[7]

References

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028458 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Toshima J, Ohashi K, Okano I, Nunoue K, Kishioka M, Kuma K, Miyata T, Hirai M, Baba T, Mizuno K (December 29, 1995). "Identification and characterization of a novel protein kinase, TESK1, specifically expressed in testicular germ cells". J. Biol. Chem. 270 (52): 31331–7. doi:10.1074/jbc.270.52.31331. PMID 8537404.
^ ^a ^b "Entrez Gene: TESK1 testis-specific kinase 1".
^ Toshima JY, Toshima J, Watanabe T, Mizuno K (November 2001). "Binding of 14-3-3beta regulates the kinase activity and subcellular localization of testicular protein kinase 1". J. Biol. Chem. 276 (46): 43471–81. doi:10.1074/jbc.M104620200. PMID 11555644.
^ Leeksma OC, Van Achterberg TA, Tsumura Y, Toshima J, Eldering E, Kroes WG, Mellink C, Spaargaren M, Mizuno K, Pannekoek H, de Vries CJ (May 2002). "Human sprouty 4, a new ras antagonist on 5q31, interacts with the dual specificity kinase TESK1". Eur. J. Biochem. 269 (10): 2546–56. doi:10.1046/j.1432-1033.2002.02921.x. PMID 12027893.

Toshima J, Tanaka T, Mizuno K (1999). "Dual specificity protein kinase activity of testis-specific protein kinase 1 and its regulation by autophosphorylation of serine-215 within the activation loop". J. Biol. Chem. 274 (17): 12171–6. doi:10.1074/jbc.274.17.12171. PMID 10207045.
Røsok O, Pedeutour F, Ree AH, Aasheim HC (1999). "Identification and characterization of TESK2, a novel member of the LIMK/TESK family of protein kinases, predominantly expressed in testis". Genomics. 61 (1): 44–54. doi:10.1006/geno.1999.5922. PMID 10512679.
Toshima J, Toshima JY, Amano T, Yang N, Narumiya S, Mizuno K (2001). "Cofilin phosphorylation by protein kinase testicular protein kinase 1 and its role in integrin-mediated actin reorganization and focal adhesion formation". Mol. Biol. Cell. 12 (4): 1131–45. doi:10.1091/mbc.12.4.1131. PMC 32292. PMID 11294912.
Toshima J, Toshima JY, Takeuchi K, Mori R, Mizuno K (2001). "Cofilin phosphorylation and actin reorganization activities of testicular protein kinase 2 and its predominant expression in testicular Sertoli cells". J. Biol. Chem. 276 (33): 31449–58. doi:10.1074/jbc.M102988200. PMID 11418599.
Toshima JY, Toshima J, Watanabe T, Mizuno K (2001). "Binding of 14-3-3beta regulates the kinase activity and subcellular localization of testicular protein kinase 1". J. Biol. Chem. 276 (46): 43471–81. doi:10.1074/jbc.M104620200. PMID 11555644.
Leeksma OC, Van Achterberg TA, Tsumura Y, Toshima J, Eldering E, Kroes WG, Mellink C, Spaargaren M, Mizuno K, Pannekoek H, de Vries CJ (2002). "Human sprouty 4, a new ras antagonist on 5q31, interacts with the dual specificity kinase TESK1". Eur. J. Biochem. 269 (10): 2546–56. doi:10.1046/j.1432-1033.2002.02921.x. PMID 12027893.
LaLonde DP, Brown MC, Bouverat BP, Turner CE (2005). "Actopaxin interacts with TESK1 to regulate cell spreading on fibronectin". J. Biol. Chem. 280 (22): 21680–8. doi:10.1074/jbc.M500752200. PMID 15817463.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000028458 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8537404-4] Toshima J, Ohashi K, Okano I, Nunoue K, Kishioka M, Kuma K, Miyata T, Hirai M, Baba T, Mizuno K (December 29, 1995). "Identification and characterization of a novel protein kinase, TESK1, specifically expressed in testicular germ cells". J. Biol. Chem. 270 (52): 31331–7. doi:10.1074/jbc.270.52.31331. PMID 8537404.

[entrez-5] "Entrez Gene: TESK1 testis-specific kinase 1".

[pmid11555644-6] Toshima JY, Toshima J, Watanabe T, Mizuno K (November 2001). "Binding of 14-3-3beta regulates the kinase activity and subcellular localization of testicular protein kinase 1". J. Biol. Chem. 276 (46): 43471–81. doi:10.1074/jbc.M104620200. PMID 11555644.

[pmid12027893-7] Leeksma OC, Van Achterberg TA, Tsumura Y, Toshima J, Eldering E, Kroes WG, Mellink C, Spaargaren M, Mizuno K, Pannekoek H, de Vries CJ (May 2002). "Human sprouty 4, a new ras antagonist on 5q31, interacts with the dual specificity kinase TESK1". Eur. J. Biochem. 269 (10): 2546–56. doi:10.1046/j.1432-1033.2002.02921.x. PMID 12027893.

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TESK1

Function

Interactions

References

Further reading