Proteinska fosfataza 2 (PP2), takođe poznata kao PP2A, je enzim koji je kod ljudi kodiran PPP2CAgenom.[1] PP2A heterotrimerna proteinska fosfataza, je široko zastupljena i konservirana serin/treoninska fosfataza sa širokom supstratnom specifičnošću i različitim ćelijskim funkcijama. Među PP2A metama su proteini onkogene signalne kaskade, poput Raf, MEK, i AKT.
Reference
^Jones TA, Barker HM, da Cruz e Silva EF, Mayer-Jaekel RE, Hemmings BA, Spurr NK, Sheer D, Cohen PT (1993). „Localization of the genes encoding the catalytic subunits of protein phosphatase 2A to human chromosome bands 5q23→q31 and 8p12→p11.2, respectively”. Cytogenet. Cell Genet. 63 (1): 35—41. PMID8383590. doi:10.1159/000133497.
Literatura
Xu Y, Xing Y, Chen Y, Chao Y, Lin Z, Fan E, Yu JW, Strack S, Jeffrey PD, Shi Y (2006). „Structure of the protein phosphatase 2A holoenzyme”. Cell. 127 (6): 1239—51. PMID17174897. doi:10.1016/j.cell.2006.11.033.
Xing Y, Xu Y, Chen Y, Jeffrey PD, Chao Y, Lin Z, Li Z, Strack S, Stock JB, Shi Y (2006). „Structure of protein phosphatase 2A core enzyme bound to tumor-inducing toxins”. Cell. 127 (2): 341—53. PMID17055435. doi:10.1016/j.cell.2006.09.025.
Ory S, Zhou M, Conrads TP, Veenstra TD, Morrison DK (2003). „Protein phosphatase 2A positively regulates Ras signaling by dephosphorylating KSR1 and Raf-1 on critical 14-3-3 binding sites”. Curr. Biol. 13 (16): 1356—64. PMID12932319. doi:10.1016/S0960-9822(03)00535-9.