Prolaktin

prolactin
Identifikatorlar
NomenklaturalactotropinPRLluteotropinlactogenluteotropic hormonelactogenic hormoneLTH
Tashqi IDlarGeneCards: [1]
Ortologiya
TurlarOdamSichqon
Entrez

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Ensembl

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UniProt

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RefSeq (mRNK)

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RefSeq (protein)

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Location (UCSC)——
PubMed——
Vikimaʼlumotlar
koʻrish/tahrirlash (odam)

Prolaktin (laktotropin nomi bilan ham ataladi) sut emizuvchilarda sut ishlab chiqarishni taʼminlashda asosiy rol oʻynaydigan proteindir. U turli umurtqalilarda, jumladan insonlarda 300 dan ortiq jarayonlarga taʼsir oʻtkazadi.[1] Prolaktin ovqatlanish, juftlashish, estrogenlar bilan davolash va ovulatsiyaga javoban gipofiz bezidan ishlab chiqariladi. Shuningdek, u metabolizm, immun sistemasi regulatsiyasi hamda meʼda osti bezi rivojlanishida muhim rol oʻynaydi.

Proklaktin 1930-yili Oscar Riddle[2] tomonidan inson boʻlmagan hayvonlarda kashf etilgan, 1970-yilda esa Henry Friesen tomonidan insonlarda tasdiqlangan.[3] Bundan tashqari, prolaktin PRL geni tomonidan kodlangan peptid gormoni hisoblanadi.[4]

Manbalar

  1. ↑ "Prolactin (PRL) and its receptor: actions, signal transduction pathways and phenotypes observed in PRL receptor knockout mice". Endocrine Reviews 19 (3): 225–68. Jun 1998. doi:10.1210/edrv.19.3.0334. PMID 9626554. 
  2. ↑ "The preparation of prolactin". Journal of Pharmacology and Experimental Therapeutics 55 (3): 365–371. November 1935. http://jpet.aspetjournals.org/content/55/3/365.abstract. 
  3. ↑ "The biosynthesis of human growth hormone and prolactin". The Journal of Clinical Endocrinology and Metabolism 31 (6): 611–24. Dec 1970. doi:10.1210/jcem-31-6-611. PMID 5483096. http://jcem.endojournals.org/content/31/6/611.abstract. [sayt ishlamaydi]
  4. ↑ "Mapping of prolactin and tumor necrosis factor-beta genes on human chromosome 6p using lymphoblastoid cell deletion mutants". Somatic Cell and Molecular Genetics 15 (3): 203–13. May 1989. doi:10.1007/BF01534871. PMID 2567059. 

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