CD44

CD44
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1POZ, 1UUH, 2I83, 4PZ3, 4PZ4
Dynodwyr
Cyfenwau	CD44, CDW44, CSPG8, ECMR-III, HCELL, HUTCH-I, IN, LHR, MC56, MDU2, MDU3, MIC4, Pgp1, CD44 molecule (Indian blood group)
Dynodwyr allanol	OMIM: 107269 HomoloGene: 508 GeneCards: CD44
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • collagen binding • GO:0001948, GO:0016582 protein binding • hyaluronic acid binding • GO:0016518 cytokine receptor activity • transmembrane signaling receptor activity Cydrannau o'r gell • integral component of membrane • Golgi apparatus • macrophage migration inhibitory factor receptor complex • bilen • focal adhesion • Cellbilen • integral component of plasma membrane • cell surface • extracellular exosome • cytosol • secretory granule membrane • apical plasma membrane • lamellipodium membrane • cell projection • microvillus • basolateral plasma membrane Prosesau biolegol • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • monocyte aggregation • positive regulation of heterotypic cell-cell adhesion • hyaluronan catabolic process • negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator • interferon-gamma-mediated signaling pathway • extracellular matrix disassembly • extracellular matrix organization • negative regulation of apoptotic process • cellular response to fibroblast growth factor stimulus • positive regulation of peptidyl-serine phosphorylation • cartilage development • cell adhesion • negative regulation of DNA damage response, signal transduction by p53 class mediator • positive regulation of ERK1 and ERK2 cascade • positive regulation of peptidyl-tyrosine phosphorylation • cell-matrix adhesion • positive regulation of monocyte aggregation • leukocyte migration • neutrophil degranulation • wound healing, spreading of cells • regulation of lamellipodium morphogenesis • cell-cell adhesion • inflammatory response • cell migration • T cell activation • positive regulation of kinase activity Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	960	n/a
Ensembl	ENSG00000026508	n/a
UniProt	P16070	n/a
RefSeq (mRNA)	NM_000610 NM_001001389 NM_001001390 NM_001001391 NM_001001392 NM_001202555 NM_001202556 NM_001202557	n/a
RefSeq (protein)	NP_000601 NP_001001389 NP_001001390 NP_001001391 NP_001001392 NP_001189484 NP_001189485 NP_001189486	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CD44 yw CD44 a elwir hefyd yn CD44 antigen (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 11, band 11p13.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CD44.

• "Nimbolide reduces CD44 positive cell population and induces mitochondrial apoptosis in pancreatic cancer cells. ". Cancer Lett. 2018. PMID 29107110.
• "CD44 Expression Is a Prognostic Factor in Patients with Intrahepatic Cholangiocarcinoma After Surgical Resection. ". Anticancer Res. 2017. PMID 28982889.
• "Akt Signaling Is Sustained by a CD44 Splice Isoform-Mediated Positive Feedback Loop. ". Cancer Res. 2017. PMID 28533273.
• "Reducing Macro- and Microheterogeneity of N-Glycans Enables the Crystal Structure of the Lectin and EGF-Like Domains of Human L-Selectin To Be Solved at 1.9 Å Resolution. ". Chembiochem. 2017. PMID 28489325.
• "Autophagy supports generation of cells with high CD44 expression via modulation of oxidative stress and Parkin-mediated mitochondrial clearance.". Oncogene. 2017. PMID 28414310.