Metirozin

Metirosin
IUPAC ime
	(2S)-2-amino- 3-(4-hidroksifenil)- 2-metilpropanoinska kiselina
Klinički podaci
Prodajno ime	Demser
Drugs.com	Potrošačka informacije o leku
Farmakokinetički podaci
Poluvreme eliminacije	3,4–3,7 sata
Identifikatori
CAS broj	672-87-7
ATC kod	C02KB01 (WHO)
PubChem	CID 10123
DrugBank	DB00765
ChemSpider	390103
UNII	DOQ0J0TPF7
KEGG	D00762
ChEMBL	CHEMBL1200862
Hemijski podaci
Formula	C10H13NO3
Molarna masa	195,215 g/mol
	SMILES O=C(O)[C@@](N)(Cc1ccc(O)cc1)C; ;
	InChI InChI=1S/C10H13NO3/c1-10(11,9(13)14)6-7-2-4-8(12)5-3-7/h2-5,12H,6,11H2,1H3,(H,13,14)/t10-/m0/s1 ; Key:NHTGHBARYWONDQ-JTQLQIEISA-N ;

Metirozin (α-Metiltirozin, Metirozin, AMPT) je antihipertenzivni lek. On inhibira enzim tirozinska hidroksilaza i, stoga sintezu kateholamina. Posledica toga je snižavanje nivoa kateholamina dopamina, adrenalina i noradrenalina u telu.

Clinical use

Metirozin je korišten u tretmanu feohromocitoma.^[1]

On se relativno retko koristi kao lek i prvenstveno nalazi primenu u naučnim istraživanjima čiji je cilj utvrđivanje uticaja iscrpljivanja kateholamina na ponašanje.^[2]

Reference

^ Green KN, Larsson SK, Beevers DG, Bevan PG, Hayes B (1982). „Alpha-methyltyrosine in the management of phaeochromocytoma”. Thorax. 37 (8): 632—3. PMC 459390 . PMID 7179194. doi:10.1136/thx.37.8.632.
^ O'Leary OF, Bechtholt AJ, Crowley JJ, Hill TE, Page ME, Lucki I. Depletion of serotonin and catecholamines block the acute behavioral response to different classes of antidepressant drugs in the mouse tail suspension test. Psychopharmacology (Berlin). 2007 Jun;192(3):357-71. O'Leary, O. F.; Bechtholt, A. J.; Crowley, J. J.; Hill, T. E.; Page, M. E.; Lucki, I. (2007). „Depletion of serotonin and catecholamines block the acute behavioral response to different classes of antidepressant drugs in the mouse tail suspension test”. Psychopharmacology. 192 (3): 357—371. PMID 17318507. doi:10.1007/s00213-007-0728-9.

Vidi još

p-Hlorofenilalanin

Spoljašnje veze

[pmid7179194-1] Green KN, Larsson SK, Beevers DG, Bevan PG, Hayes B (1982). „Alpha-methyltyrosine in the management of phaeochromocytoma”. Thorax. 37 (8): 632—3. PMC 459390 . PMID 7179194. doi:10.1136/thx.37.8.632.

[2] O'Leary OF, Bechtholt AJ, Crowley JJ, Hill TE, Page ME, Lucki I. Depletion of serotonin and catecholamines block the acute behavioral response to different classes of antidepressant drugs in the mouse tail suspension test. Psychopharmacology (Berlin). 2007 Jun;192(3):357-71. O'Leary, O. F.; Bechtholt, A. J.; Crowley, J. J.; Hill, T. E.; Page, M. E.; Lucki, I. (2007). „Depletion of serotonin and catecholamines block the acute behavioral response to different classes of antidepressant drugs in the mouse tail suspension test”. Psychopharmacology. 192 (3): 357—371. PMID 17318507. doi:10.1007/s00213-007-0728-9.

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