丙酸氟替卡松

丙酸氟替卡松
臨床資料
商品名（英语：Drug nomenclature）Flovent, Flixotide, Flonase, others
AHFS/Drugs.comMonograph
MedlinePlusa695002
核准狀況
懷孕分級
给药途径鼻腔给药,[2] 吸入劑型,[3] 外用藥物[4]
藥物類別類固醇及其衍生物
ATC碼
法律規範狀態
法律規範
藥物動力學數據
生物利用度0.51% (鼻內劑)
血漿蛋白結合率91%
药物代谢Intranasal
肝臟 (透過CYP3A4)
生物半衰期10 小時
排泄途徑腎
识别信息
  • S-(fluoromethyl)-6α,9-difluoro-11β, 17-dihydroxy-16α-methyl-3-oxoandrosta-1, 4-diene-17β-carbothioate, 17-propanoate
CAS号80474-14-2  checkY
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)
ECHA InfoCard100.129.097 編輯維基數據鏈接
化学信息
化学式C25H31F3O5S
摩尔质量500.57 g·mol−1
3D模型（JSmol（英语：JSmol））
  • CCC(=O)OC1(C(CC2C1(CC(C3(C2CC(C4=CC(=O)C=CC43C)F)F)O)C)C)C(=O)SCF
  • InChI=1S/C25H31F3O5S/c1-5-20(31)33-25(21(32)34-12-26)13(2)8-15-16-10-18(27)17-9-14(29)6-7-22(17,3)24(16,28)19(30)11-23(15,25)4/h6-7,9,13,15-16,18-19,30H,5,8,10-12H2,1-4H3/t13-,15+,16+,18+,19+,22+,23+,24+,25+/m1/s1 checkY
  • Key:WMWTYOKRWGGJOA-CENSZEJFSA-N checkY

丙酸氟替卡松（INN：Fluticasone propionate）又名氟替卡松丙酸酯。它是一种类固醇药物[8]。吸入劑型用于长期治疗哮喘和慢性阻塞性肺病[8]。鼻噴劑型用于治疗花粉症鼻炎和鼻息肉[9][10] In 2022, fluticasone was the 25th most commonly prescribed medication in the United States, with more than 22 million prescriptions.[11][12]。也可治疗口腔溃疡[13]。

吸入劑的常见副作用包括上呼吸道感染、鼻竇炎、鹅口疮和咳嗽[8]。鼻用劑型的常见副作用包括流鼻血和喉咙痛[9]。主要作用可以减少炎症反應[8]。

丙酸氟替卡松于 1980 年获得专利，于 1990 年取得醫療使用許可[14]。已有學名药流通於市[10]。2018 年，它是美国最常用的处方药第十六名，共開立超过 3千4百万张处方[15] [16]。

参考文獻

  1. ^ Fluticasone Use During Pregnancy. Drugs.com. 9 January 2019 [31 January 2020]. （原始内容存档于26 March 2019）. 
  2. ^ Flonase Allergy Relief- fluticasone propionate spray, metered. DailyMed. 30 May 2019 [31 January 2020]. （原始内容存档于2 December 2020）. 
  3. ^ Flovent Diskus- fluticasone propionate powder, metered. DailyMed. 7 January 2019 [31 January 2020]. （原始内容存档于7 December 2019）. 
  4. ^ 4.0 4.1 Cutivate- fluticasone propionate lotion. DailyMed. 8 August 2018 [19 February 2022]. （原始内容存档于20 February 2022）. 
  5. ^ Prescription medicines: registration of new generic medicines and biosimilar medicines, 2017. Therapeutic Goods Administration (TGA). 21 June 2022 [30 March 2024]. 
  6. ^ Respiratory health. Health Canada. 9 May 2018 [13 April 2024]. 
  7. ^ Flixonase Aqueous Nasal Spray - Summary of Product Characteristics (SmPC). (emc). 25 October 2019 [31 January 2020]. （原始内容存档于31 January 2020）. 
  8. ^ 8.0 8.1 8.2 8.3 Fluticasone Propionate Monograph for Professionals. Drugs.com. American Society of Health-System Pharmacists. [27 February 2019]. （原始内容存档于28 February 2019）. 
  9. ^ 9.0 9.1 Fluticasone Propionate eent Monograph for Professionals. Drugs.com. American Society of Health-System Pharmacists. [27 February 2019]. （原始内容存档于28 February 2019）. 
  10. ^ 10.0 10.1 British national formulary : BNF 76 76. Pharmaceutical Press. 2018: 262, 1172. ISBN 9780857113382. 
  11. ^ The Top 300 of 2022. clincalc.com. [2024-08-19]. 
  12. ^ Fluticasone - Drug Usage Statistics. ClinCalc. [14 January 2024]. 
  13. ^ Flixonase aqueous spray (PDF). Sheffield Teaching Hospitals. June 2018 [31 January 2020]. （原始内容存档 (PDF)于25 September 2019）. 
  14. ^ Fischer, János; Ganellin, C. Robin. Analogue-based Drug Discovery. John Wiley & Sons. 2006: 487 [28 February 2019]. ISBN 9783527607495. （原始内容存档于28 February 2019）. 
  15. ^ The Top 300 of 2021. ClinCalc. [18 February 2021]. （原始内容存档于12 February 2021）. 
  16. ^ Fluticasone - Drug Usage Statistics. ClinCalc. [18 February 2021]. （原始内容存档于12 April 2020）. 

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