4-羟基雌酮
4-羟基雌酮
IUPAC名 (8R ,9S ,13S ,14S )-3,4-Dihydroxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H -cyclopenta[a ]phenanthren-17-one
别名
4-OHE1; Estra-1,3,5(10)-triene-3,4-diol-17-one; 3,4-Dihydroxyestra-1,3,5(10)-trien-17-one
识别
CAS号
3131-23-5 Y
PubChem
9971251
ChemSpider
8146843
SMILES
C[C@]12CC[C@H]3[C@H]([C@@H]1CCC2=O)CCC4=C3C=CC(=C4O)O
ChEBI
87602
性质
化学式
C18 H22 O3
摩尔质量
286.37 g·mol−1
熔点
260—265 °C(533—538 K)[ 1]
若非注明,所有数据均出自标准状态(25 ℃,100 kPa) 下。
4-羟基雌酮 (英語:4-Hydroxyestrone ,缩写4-OHE1 ,或称为“雌甾-1,3,5(10)-三烯-3,4-二醇-17-酮”,estra-1,3,5(10)-trien-3,4-diol-17-one )是一种天然 内源 性的儿茶酚雌激素 和雌酮 与雌二醇 的次要代謝產物 [ 2] [ 3] [ 4] 。它具有微量的雌激素 活性,与2-羟基雌二醇 、16α-羟基雌酮 、雌三醇 (16α-羟基雌二醇)和4-羟基雌二醇 等其它羟基雌二醇 类似,但不同于2-羟基雌酮 [ 2] [ 5] 。
参考资料
^ Jack Fishman, Maria Tomasz, Rosemarie Lehman. Catechol Derivatives of Estrogens 1 . The Journal of Organic Chemistry. 1960-04, 25 (4): 585–588 [2021-01-27 ] . ISSN 0022-3263 . doi:10.1021/jo01074a026 (英语) .
^ 2.0 2.1 Oettel M, Schillinger E. Estrogens and Antiestrogens I: Physiology and Mechanisms of Action of Estrogens and Antiestrogens . Springer Science & Business Media. 6 December 2012: 224, 232, 244–245, 249. ISBN 978-3-642-58616-3 .
^ Rakel D. Integrative Medicine . Elsevier Health Sciences. 2012: 338–. ISBN 978-1-4377-1793-8 .
^ Buchsbaum HJ. The Menopause . Springer Science & Business Media. 6 December 2012: 64–65. ISBN 978-1-4612-5525-3 .
^ Bhavnani BR, Nisker JA, Martin J, Aletebi F, Watson L, Milne JK. Comparison of pharmacokinetics of a conjugated equine estrogen preparation (premarin) and a synthetic mixture of estrogens (C.E.S.) in postmenopausal women. Journal of the Society for Gynecologic Investigation. 2000, 7 (3): 175–83. PMID 10865186 . doi:10.1016/s1071-5576(00)00049-6 .
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